| Gene Symbol |
HS3ST3B1
|
| Entrez Gene |
9953
|
| Alt Symbol |
3-OST-3B, 3OST3B1, h3-OST-3B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
|
| Other Description |
heparan sulfate 3-O-sulfotransferase 3B1|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1|heparan sulfate glucosamine 3-O-sulfotransferase 3B1
|
| Swissprots |
D3DTS6 Q9Y662 B3KN58
|
| Accessions |
EAW89953 EAW89954 Q9Y662 AF105377 AAD30209 AK023723 BAG51220 BC063301 AAH63301 BC069664 AAH69664 BC069725 AAH69725 BM968044 DA388077 XR_934130 NM_006041 NP_006032 NR_130138
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:10520990}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney. {ECO:0000269|PubMed:9988767}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|