Gene Symbol | HS3ST3B1 |
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Entrez Gene | 9953 |
Alt Symbol | 3-OST-3B, 3OST3B1, h3-OST-3B |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 |
Other Description | heparan sulfate 3-O-sulfotransferase 3B1|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1|heparan sulfate glucosamine 3-O-sulfotransferase 3B1 |
Swissprots | D3DTS6 Q9Y662 B3KN58 |
Accessions | EAW89953 EAW89954 Q9Y662 AF105377 AAD30209 AK023723 BAG51220 BC063301 AAH63301 BC069664 AAH69664 BC069725 AAH69725 BM968044 DA388077 XR_934130 NM_006041 NP_006032 NR_130138 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:10520990}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney. {ECO:0000269|PubMed:9988767}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
HS3ST3B1 (E-13) - sc-107606 from Santa Cruz Biotechnology
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HS3ST3B1 (G-12) - sc-107607 from Santa Cruz Biotechnology
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HS3ST3B1 (P-13) - sc-107609 from Santa Cruz Biotechnology
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Anti-HS3ST3B1 antibody - ab105322 from Abcam
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Anti-HS3ST3B1 Antibody (aa38-87) - LS-C80919 from LifeSpan Bioscience
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Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3 Antibody - AF7276 from Novus Biologicals
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Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3 Antibody - NBP1-91295 from Novus Biologicals
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Anti-HS3ST3B1 antibody produced in rabbit - SAB2101081 from Sigma-Aldrich
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HS3ST3B1 antibody - N-terminal region (ARP46685_P050) - ARP46685_P050 from Aviva Systems Biology
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HS3ST3B1 antibody, N-term - GTX46416 from GeneTex
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Human Heparan Sulfate Glucosamine 3‑O‑Sulfotransferase 3 Antibody - AF7276 from R&D Systems
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Human HS3ST3B1 Affinity Purified Polyclonal Ab, Sheep IgG - AF7276-SP from R&D Systems
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HS3ST3B1 antibody - 70R-6860 from Fitzgerald
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HS3ST3B1 Antibody - GWB-MQ526D from Genway Biotech
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HS3ST3B1-antibody-N-terminal-region-AI12703 - AI12703 from Abgent, a WuXi AppTec company
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HS3ST3B1, Polyclonal Antibody - MBS5303391 from MyBioSource
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Anti-HS3ST3B1 antibody produced in rabbit - SAB2108153 from Sigma-Aldrich
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HS3ST3B1 / 3OST3B1 antibody - TA339032 from Acris Antibodies
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Anti-HS3ST3B1 (aa 38-87) polyclonal antibody - CABT-BL1853 from Creative Diagnostics
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Anti-HS3ST3B1 Antibody A10912 - A10912 from Boster Bio
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HS3ST3B1 antibody - N-terminal region : Biotin (ARP46685_P050-Biotin) - ARP46685_P050-Biotin from Aviva Systems Biology
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HS3ST3B1 antibody - N-terminal region : FITC (ARP46685_P050-FITC) - ARP46685_P050-FITC from Aviva Systems Biology
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HS3ST3B1 antibody - N-terminal region : HRP (ARP46685_P050-HRP) - ARP46685_P050-HRP from Aviva Systems Biology
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Anti-HS3ST3B1 Antibody (aa38-87, Biotin) - LS-C449103 from LifeSpan Bioscience
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Anti-HS3ST3B1 Antibody (aa38-87, HRP) - LS-C449105 from LifeSpan Bioscience
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