LRRFIP1

Gene Symbol LRRFIP1
Entrez Gene 9208
Alt Symbol FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP
Species Human
Gene Type protein-coding
Description leucine rich repeat (in FLII) interacting protein 1
Other Description GC-binding factor 2|LRR FLII-interacting protein 1|NEDD8-conjugating enzyme|TAR RNA-interacting protein|leucine-rich repeat flightless-interacting protein 1
Swissprots Q32MZ5 O75766 Q6PKG2 Q53T49 E9PGZ2 Q9Y607 Q32MZ4 O75799
Accessions AAY14672 AAY14673 EAW71122 EAW71123 EAW71124 EAW71125 Q32MZ4 AA975133 AF115510 AAD41258 AJ223075 CAA11076 AK000884 AK298270 BAG60532 AK307485 BC001385 AAH01385 BC004958 BC010662 AAH10662 BC018883 BC019335 AAH19335 BC071618 BC083492 BC108913 AAI08914 BC108914 AAI08915 BE390005 BG699031 BU685896 EU831431 ACE87118 EU831523 ACE86442 EU832771 ACE87782 EU832772 ACE87783 GQ129315 ACT64449 GQ129316 ACT64450 U69609 AAC32037 XM_005246112 XP_005246169 XM_005246115 XP_005246172 XM_005246116 XP_005246173 XM_005246118 XP_005246175 XM_005246119 XP_005246176 XM_005246120 XP_005246177 XM_005246121 XP_005246178 XM_005246122 XP_005246179 XM_005246124 XP_005246181 XM_005246125 XP_005246182 XM_005246126 XP_005246183 XM_005246128 XP_005246185 XM_005246129 XP_005246186 XM_005246130 XP_005246187 XM_005246131 XP_005246188 XM_005246132 XP_005246189 XM_005246133 XP_005246190 XM_005246134 XP_005246191 XM_005246135 XP_005246192 XM_005246136 XP_005246193 XM_005246141 XP_005246198 XM_005246142 XP_005246199 XM_006712842 XP_006712905 XM_006712843 XP_006712906 XM_006712844 XP_006712907 XM_006712845 XP_006712908 XM_006712846 XP_006712909 XM_006712847 XP_006712910 XM_006712848 XP_006712911 XM_011512152 XP_011510454 XM_011512153 XP_011510455 XM_011512154 XP_011510456 XM_011512155 XP_011510457 XM_011512156 XP_011510458 XM_011512157 XP_011510459 XM_011512158 XP_011510460 XM_011512159 XP_011510461 XM_011512160 XP_011510462 XM_011512161 XP_011510463 XM_011512162 XP_011510464 XM_011512163 XP_011510465 XM_011512164 XP_011510466 XM_011512165 XP_011510467 XM_011512166 XP_011510468 XR_923063 NM_001137550 NP_001131022 NM_001137551 NP_001131023 NM_001137552 NP_001131024 NM_001137553 NP_001131025 NM_004735 NP_004726
Function Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:9671805, ECO:0000269|PubMed:9705290}.

LRRFIP1 (C-3) - sc-398240 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRRFIP1 (C-3): sc-398240. Western blot analysis of LRRFIP1 expression in Jurkat whole cell lysate.

LRRFIP1 (32) - sc-135917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
LRRFIP1 (32): sc-135917. Western blot analysis of LRRFIP1 expression in A-431 whole cell lysate.

LRRFIP1 (G-4) - sc-514221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRRFIP1 (G-4): sc-514221. Western blot analysis of LRRFIP1 expression in HeLa (A), Jurkat (B) and A-431 (C) whole cell lysates.

LRRFIP1 (H-227) - sc-68385 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRRFIP1 (H-227): sc-68385. Western blot analysis of LRRFIP1 expression in non-transfected: sc-117752 (A) and human LRRFIP1 transfected: sc-177272 (B) 293T whole cell lysates.

LRRFIP1 (J-14) - sc-101168 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
LRRFIP1 (J-14): sc-101168. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human small Intestine tissue showing cytoplasmic localization.

LRRFIP1 (C-18) - sc-66677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRRFIP1 (C-18): sc-66677. Western blot analysis of human recombinant LRRFIP1 fusion protein.

LRRFIP1 (N-16) - sc-66682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRRFIP1 (N-16): sc-66682. Western blot analysis of LRRFIP1 expression in HeLa (A) and Jurkat (B) whole cell lysates.

Anti-LRRFIP1 antibody - ab77598 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-LRRFIP1 antibody (ab77598) at 1/500 dilution + recombinant fragment of human LRRFIP1 (the immunogen) at 0.2 µgSecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-LRRFIP1 antibody - ab56486 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
LRRFIP1 antibody (ab56486) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-LRRFIP1 antibody - ab168976 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-LRRFIP1 antibody (ab168976) at 1/500 dilutionLane 1 : LRRFIP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-LRRFIP1 antibody - ab176587 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of LRRFIP1 in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab176587 at 6 µg/mg lysate for IP (Lane 1). For WB detection ab176587 was used at 0.4 µg/ml. Lane 2 represents control IgG IP.Detection: Chemiluminescence with an exposure time of 1 second.

Anti-LRRFIP1 antibody - ab103148 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LRRFIP1 antibody (ab103148) at 1/500 dilution + NIH 3T3 cell lysate at 50 µg

Anti-LRRFIP1 antibody - ab133218 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human prostate tissue labelling LRRFIP1 with ab133218 at 5µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TRIP / LRRFIP1 Antibody (aa35-84) IHC-plus™ - LS-B11986 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-TRIP / LRRFIP1 Antibody (aa690-707) IHC-plus™ - LS-B3098 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LRRFIP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3098 concentration 5 ug/ml.

Anti-TRIP / LRRFIP1 Antibody (aa520-569) - LS-C145924 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRRFIP1 antibody LS-C145924 Western blot of Small Intestine lysate. Antibody concentration 1 ug/ml.

Anti-TRIP / LRRFIP1 Antibody (aa411-460) - LS-C116869 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRRFIP1 antibody LS-C116869 Western blot of U937 cell lysate.

Anti-TRIP / LRRFIP1 Antibody (aa50-100) - LS-C289779 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIP / LRRFIP1 Antibody (aa500-550) - LS-C289780 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIP / LRRFIP1 Antibody (aa758-808) - LS-C289781 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIP / LRRFIP1 Antibody (aa200-250) - LS-C148697 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of LRRFIP1 in human heart lysate using 1) pre-bleed and 2) LS-C148697, and LS-C148697 in 3) mouse heart lysate at 3 and 5 ug/ml, respectively. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-TRIP / LRRFIP1 Antibody (aa128-250, Biotin) - LS-C299186 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRIP / LRRFIP1 Antibody (aa615-735, Biotin) - LS-C300361 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRIP / LRRFIP1 Antibody (aa615-735, FITC) - LS-C302172 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRIP / LRRFIP1 Antibody - LS-C178287 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot detection of LRRFIP1 in Raji,C2C12,MCF7&Jurkat cell lysates using LRRFIP1 antibody (1:1000 diluted).
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