PAK7

Gene Symbol PAK7
Entrez Gene 57144
Alt Symbol PAK5
Species Human
Gene Type protein-coding
Description p21 protein (Cdc42/Rac)-activated kinase 7
Other Description PAK-5|PAK-7|p21(CDKN1A)-activated kinase 7|p21-activated kinase 5|p21-activated kinase 7|p21CDKN1A-activated kinase 7|protein kinase PAK5|serine/threonine-protein kinase PAK 7|serine/threonine-protein kinase PAK7
Swissprots Q9P286 Q9BX09 A8K5T6 Q5W115 Q9ULF6 D3DW14
Accessions EAX10357 EAX10358 EAX10359 EAX10360 Q9P286 AB033090 BAA86578 AB040812 BAA94194 AK095674 BAG53104 AK291401 BAF84090 AK307926 AK315820 BAF98711 AL133002 CAB61350 AX776013 CAE11706 BC024179 AAH24179 DQ890894 ABM81820 DQ894048 ABM84974 XM_005260766 XP_005260823 XM_006723597 XP_006723660 XM_011529308 XP_011527610 NM_020341 NP_065074 NM_177990 NP_817127
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
Subcellular Location Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Tissue Specificity Predominantly expressed in brain.
Top Pathways Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

PAK5 (S-16) - sc-22155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAK5 (S-16): sc-22155. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing nuclear staining of cells in tubules.

PAK5 (H-20) - sc-22156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PAK5 antibody - ab110069 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PAK5 antibody (ab110069) at 1/500 dilutionLane 1 : extracts from Rat brain cellsLane 2 : extracts from Rat brain cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-PAK5 antibody - ab37753 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFa-fixed paraffin-embedded sections) analysis of human brain tissue labelling PAK5 with ab37753. A peroxidase-conjugated anti-rabbit IgG was used as the secondary antibody, followed by DAB staining.

Anti-PAK5 antibody - ab62510 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-PAK5 antibody (ab62510) at 2 µg/mlLane 2 : Anti-PAK5 antibody (ab62510) at 4 µg/mlLane 1 : T24 lysateLane 2 : T24 lysateLysates/proteins at 15 µg per lane.

Anti-PAK5 antibody - ab140924 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labelling PAK5 with ab140924 at 5 µg/ml.

Anti-PAK5 antibody - N-terminal - ab171761 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of formalin fixed and paraffin embedded mouse brain tissue labeling PAK5 with ab171761 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-PAK7 Antibody - LS-C147040 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (Internal) IHC-plus™ - LS-A7963 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PAK7 antibody IHC of human brain, substantia nigra neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PAK7 Antibody (Internal) IHC-plus™ - LS-B1385 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PAK7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1385 concentration 5 ug/ml.

Anti-PAK7 Antibody (Glu693) - LS-C193193 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa128-157, AP) - LS-C265514 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa128-157, APC) - LS-C265515 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa128-157, Biotin) - LS-C265517 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa128-157, FITC) - LS-C265518 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa128-157, Azide-free, HRP) - LS-C265519 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa128-157, PE) - LS-C265520 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198, AP) - LS-C280523 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198, APC) - LS-C280525 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198, Biotin) - LS-C280526 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198, Azide-free, HRP) - LS-C280527 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198, PE) - LS-C280528 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198, FITC) - LS-C280540 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa127-157) - LS-C323767 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK7 Antibody (aa183-198) - LS-C328136 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more