PAK7

Gene Symbol	PAK7
Entrez Gene	57144
Alt Symbol	PAK5
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 7
Other Description	PAK-5|PAK-7|p21(CDKN1A)-activated kinase 7|p21-activated kinase 5|p21-activated kinase 7|p21CDKN1A-activated kinase 7|protein kinase PAK5|serine/threonine-protein kinase PAK 7|serine/threonine-protein kinase PAK7
Swissprots	Q9P286 Q9BX09 A8K5T6 Q5W115 Q9ULF6 D3DW14
Accessions	EAX10357 EAX10358 EAX10359 EAX10360 Q9P286 AB033090 BAA86578 AB040812 BAA94194 AK095674 BAG53104 AK291401 BAF84090 AK307926 AK315820 BAF98711 AL133002 CAB61350 AX776013 CAE11706 BC024179 AAH24179 DQ890894 ABM81820 DQ894048 ABM84974 XM_005260766 XP_005260823 XM_006723597 XP_006723660 XM_011529308 XP_011527610 NM_020341 NP_065074 NM_177990 NP_817127
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
Subcellular Location	Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Tissue Specificity	Predominantly expressed in brain.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

p21 protein (Cdc42/Rac) -activated kinase 7, ELISA Kit - MBS9335153 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PAK7 ELISA Kit - E028067 from Biobool Category ELISA Kit

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9373972 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9381727 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9381367 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9379337 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9373882 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9375922 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9373253 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9380528 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9372141 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9372917 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9373428 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9379304 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9371925 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9380656 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9380106 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9373703 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9381065 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9374069 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9375032 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9379810 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/Threonine-Protein Kinase PAK 7 (PAK7), ELISA Kit - MBS9373284 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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