PAK7

Gene Symbol	PAK7
Entrez Gene	57144
Alt Symbol	PAK5
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 7
Other Description	PAK-5|PAK-7|p21(CDKN1A)-activated kinase 7|p21-activated kinase 5|p21-activated kinase 7|p21CDKN1A-activated kinase 7|protein kinase PAK5|serine/threonine-protein kinase PAK 7|serine/threonine-protein kinase PAK7
Swissprots	Q9P286 Q9BX09 A8K5T6 Q5W115 Q9ULF6 D3DW14
Accessions	EAX10357 EAX10358 EAX10359 EAX10360 Q9P286 AB033090 BAA86578 AB040812 BAA94194 AK095674 BAG53104 AK291401 BAF84090 AK307926 AK315820 BAF98711 AL133002 CAB61350 AX776013 CAE11706 BC024179 AAH24179 DQ890894 ABM81820 DQ894048 ABM84974 XM_005260766 XP_005260823 XM_006723597 XP_006723660 XM_011529308 XP_011527610 NM_020341 NP_065074 NM_177990 NP_817127
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
Subcellular Location	Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Tissue Specificity	Predominantly expressed in brain.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PAK5 full length protein - ab60754 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PAK5 protein fragment - ab95311 from Abcam Category Protein Prices $761.00 Sizes 10 µg Source E. coli Species Human

PAK7 Antibody Blocking Peptide - LS-E2949 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK7 Antibody Blocking Peptide - LS-E30007 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK7 Antibody Blocking Peptide - LS-E9376 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK7 Antibody Blocking Peptide - LS-E29251 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK7 Antibody Blocking Peptide - LS-E29295 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK5 Recombinant Protein - P4211 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PAK5 Recombinant Protein - P4745 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PAK5 Blocking Peptide - NBP1-77237PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PAK5-Antibody-Blocking-Peptide - BP7930a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAK7 (Active) recombinant protein - GTX65434 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human PAK7 protein - orb246656 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PAK7 Blocking Peptide - 33R-11002 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PAK7 protein - 30R-2842 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

PAK7 Blocking Peptide - abx063928 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

PAK7 / PAK5 - P4211 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PAK7 / PAK5 - P4745 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PAK7 / PAK5 - P5385 from Acris Antibodies Category Protein Prices $670.00 Sizes 10 µg Species Human

PAK7 / PAK5 Control Peptide - AP30643CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PAK5 Peptide - 3075P from ProSci Category Peptide Species Human

PAK7 fusion protein - Ag3127 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PAK7, GST-tagged, Active - PAK7-382H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 7 - PAK7-522H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human PAK7, GST-His - PAK7-725H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

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