ZYX

Gene Symbol ZYX
Entrez Gene 7791
Alt Symbol ESP-2, HED-2
Species Human
Gene Type protein-coding
Description zyxin
Other Description zyxin-2
Swissprots A4D2G6 Q6I9S4 B4DQX7 Q15942
Accessions AAS07459 CBX47470 CBX47471 EAL23788 EAW51848 EAW51849 EAW51850 EAW51851 Q15942 AK130138 AK298925 BAG61030 AK299005 BAG61089 AK302309 BAG63647 AK316227 BAH14598 BC002323 AAH02323 BC008743 AAH08743 BC009360 AAH09360 BC010031 AAH10031 BC017183 AAH17183 BU844538 CR457431 CAG33712 DQ892925 ABM83851 DQ896174 ABM87173 U15158 AAA78902 X94991 CAA64447 X95735 CAA65050 XM_011516567 XP_011514869 XM_011516568 XP_011514870 XM_011516569 XP_011514871 NM_001010972 NP_001010972 NM_003461 NP_003452
Function Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
Top Pathways Focal adhesion

Phospho-Zyxin (Ser142/143) Antibody - 4863 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A-431 cells, untreated (-) or EGF-treated (30 min; +), using Phospho-Zyxin (Ser142/143) Antibody (upper) and Zyxin Antibody #3553 (lower).

Phospho-Zyxin (Ser142/143) (D1E8) Rabbit mAb - 8467 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1E8
Western blot analysis of extracts from A-431 and U-2 OS cells, untreated (-) or treated (+) with λ and calf intestinal phosphatase (λ/CIP), using Phospho-Zyxin (Ser142/143) (D1E8) Rabbit mAb (upper) or Zyxin Antibody #3553 (lower).

Zyxin Antibody - 3553 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Zyxin Antibody.

Zyxin (C-19) - sc-6437 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zyxin (C-19) PE: sc-6437 PE. Intracellular FCM analysis of fixed and permeabilized HeLa cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

Zyxin (N-19) - sc-6438 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zyxin (N-19) PE: sc-6438 PE. Intracellular FCM analysis of fixed and permeabilized HeLa cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

Zyxin (H-200) - sc-15338 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Zyxin (H-200): sc-15338. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic and membrane staining of epidermal cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Zyxin (21) - sc-136128 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Zyxin (21): sc-136128. Western blot analysis of Zyxin expression in SL-29 whole cell lysate.

Anti-Zyxin (phospho S142) antibody - ab78910 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Zyxin (phospho S142) antibody (ab78910) at 1/500 dilutionLane 1 : Extracts from Jurkat cells, treated with paclitaxel (1uM, 24hours)Lane 2 : Extracts from Jurkat cells, treated with paclitaxel (1uM, 24hours) with immunising phosphopeptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Zyxin antibody - ab71842 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Zyxin antibody (ab71842) at 1 µg/mlLane 1 : SK N SH (Human neuroblastoma) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 3 : A498 (Human Kidney Carcinoma) Whole Cell LysateLane 4 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell LysateLane 5 : DU 145 (Human prostate carcinoma cell line) Whole Cell LysateLane 6 : Testis (Rat) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Zyxin antibody - ab11518 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Zyxin antibody - ab58210 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Zyxin antibody - ab28720 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Zyxin antibody (ab28720) at 1.25 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP-conjugated anti-rabbit IgGObserved band size : 61 kDa (why is the actual band size different from the predicted?)

Anti-Zyxin antibody [2D1] - ab110202 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D1
ab110202 at 5 µg/ml, staining Zyxin in Formalin-Fixed, Paraffin-Embedded Human testis tissue.

Anti-Zyxin antibody [EPR4302] - ab109316 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4302
Overlay histogram showing HeLa cells stained with ab109316 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109316, 1/10000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Zyxin antibody [ZOL301] - ab50391 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone ZOL301
ab50391 staining rat neuronal progenitor cells by ICC/IF.  Cells were PFA fixed and permeabilized in 0.2% Triton X100 for 5 minutes prior to blocking in 10% serum at RT for 1 hour.  The primary antibody was incubated with the sample for 1 hour at 4 µg/ml.  An Alexa Fluor® 488 conjugated goat anti-mouse antibody diluted 1/1000 was used as the secondary.See Abreview

Anti-Zyxin Antibody (aa1-573) - LS-C40282 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-Zyxin Antibody (N-Terminus) - LS-C133000 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Zyxin Antibody (aa307-356) - LS-C31291 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-Zyxin Antibody (aa384-572, Biotin) - LS-C299229 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Zyxin Antibody (aa377-523, Biotin) - LS-C300088 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Zyxin Antibody (aa384-572, FITC) - LS-C301374 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Zyxin Antibody (aa251-300) - LS-C109905 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ZYX / Zyxin antibody LS-C109905 Western blot of Fetal Stomach lysate.

Anti-Zyxin Antibody (aa377-523, FITC) - LS-C304651 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Zyxin Antibody (aa327-339) - LS-C108926 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ZYX antibody (0.1 ug/ml) staining of Peripheral Blood Mononucleocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Zyxin Antibody - LS-C192939 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of HeLa cell lines, using ZYX antibody.
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