Gene Symbol | KIF23 |
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Entrez Gene | 9493 |
Alt Symbol | CHO1, KNSL5, MKLP-1, MKLP1 |
Species | Human |
Gene Type | protein-coding |
Description | kinesin family member 23 |
Other Description | kinesin-like 5 (mitotic kinesin-like protein 1)|kinesin-like protein KIF23 |
Swissprots | Q8WVP0 B4E1K0 Q02241 |
Accessions | EAW77841 EAW77842 Q02241 AA291944 AI131325 AK303874 BAG64812 AK308322 AK308361 AK310402 AU133373 BC017705 AAH17705 BC051826 AAH51826 BG939827 BI093060 BX327654 BX477359 DB445953 DR000298 EU176620 ABW03421 X67155 CAA47628 XM_005254796 XP_005254853 XM_005254797 XP_005254854 XM_005254798 XP_005254855 XM_005254799 XP_005254856 XM_011522238 XP_011520540 XM_011522239 XP_011520541 XM_011522240 XP_011520542 NM_001281301 NP_001268230 NM_004856 NP_004847 NM_138555 NP_612565 |
Function | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702}. |
Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis. |
Top Pathways | MicroRNAs in cancer |
MKLP-1 CRISPR/Cas9 KO Plasmid (h) - sc-400696 from Santa Cruz Biotechnology
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MKLP-1 HDR Plasmid (h) - sc-400696-HDR from Santa Cruz Biotechnology
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MKLP-1 Double Nickase Plasmid (h) - sc-400696-NIC from Santa Cruz Biotechnology
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MKLP-1 Double Nickase Plasmid (h2) - sc-400696-NIC-2 from Santa Cruz Biotechnology
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MKLP-1 CRISPR Activation Plasmid (h) - sc-400696-ACT from Santa Cruz Biotechnology
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MKLP-1 CRISPR Activation Plasmid (h2) - sc-400696-ACT-2 from Santa Cruz Biotechnology
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MKLP-1 Lentiviral Activation Particles (h) - sc-400696-LAC from Santa Cruz Biotechnology
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MKLP-1 Lentiviral Activation Particles (h2) - sc-400696-LAC-2 from Santa Cruz Biotechnology
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MKLP-1 siRNA (h) - sc-35936 from Santa Cruz Biotechnology
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MKLP-1 shRNA Plasmid (h) - sc-35936-SH from Santa Cruz Biotechnology
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MKLP-1 shRNA (h) Lentiviral Particles - sc-35936-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU066121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11190 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11190 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04745 from Sigma-Aldrich
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KIF23 siRNA (Human) - CRH6303 from Cohesion Biosciences
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shRNA set against Human KIF23 (NM_004856.5) - SHH325183 from Creative biogene
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KIF23 shRNA Plasmid (Human) - CHH6303 from Cohesion Biosciences
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KIF23 miRNA 3'UTR clone - MiUTR3H-07335 from Creative biogene
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KIF23 miRNA 3'UTR clone - MiUTR3H-07336 from Creative biogene
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