BIRC7

Gene Symbol BIRC7
Entrez Gene 79444
Alt Symbol KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 7
Other Description RING finger protein 50|baculoviral IAP repeat-containing protein 7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|melanoma inhibitor of apoptosis protein
Swissprots Q96CA5 Q9BQV0 Q9HAP7 Q9H2A8
Accessions CAC37337 CAC37338 EAW75302 EAW75303 EAW75304 Q96CA5 AF301009 AAG37878 AF311388 AAG33622 AY358835 AAQ89194 AY358836 AAQ89195 AY517497 AAS01729 BC014475 AAH14475 BU737800 DQ893077 ABM84003 DQ896338 ABM87337 NM_022161 NP_071444 NM_139317 NP_647478
Function Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isof
Subcellular Location Nucleus {ECO:0000269|PubMed:17294084}. Cytoplasm {ECO:0000269|PubMed:17294084}. Golgi apparatus {ECO:0000269|PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Tissue Specificity Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
Top Pathways Apoptosis, Ubiquitin mediated proteolysis, Small cell lung cancer, Toxoplasmosis

Human BIRC7 / Livin ELISA Kit (Custom ELISA) - LS-F358 from LifeSpan Bioscience

Category ELISA Kit
Prices $730.00, $1,290.00, $2,950.00
Sizes 1 plate, 2 plate, 5 plate
Sensitivity To be determined
Range 0.78-50 ng/ml

Human BIRC7 / Livin ELISA Kit (Sandwich ELISA) - LS-F10508 from LifeSpan Bioscience

Category ELISA Kit
Prices $490.00
Sizes 1 plate
Sensitivity 20 pg/ml
Range 0.78-50 ng/ml

Human BIRC7 / Baculoviral IAP Repeat-containing Protein 7 ELISA Kit - RAB0710 from Sigma-Aldrich

Category ELISA Kit
Prices $805.00
Sizes 1 kt

Anti Livin Antibody BioAssay™ ELISA Kit (Human) - 179956 from USBiological Life Science

Category ELISA Kit
Sensitivity 0.1ng/mL
Range 0.5-10ng/mL

Anti-livin antibody, Human, ELISA Kit - E01A0023 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t
Sensitivity 0.1 ng/mL
Range 0.5-10 ng/mL

Custom Human Livin ELISA - ELH-Livin from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Anti-livin ELISA Kit - HA0030 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Human BIRC7(Baculoviral IAP repeat-containing protein 7) ELISA Kit - E-EL-H5455 from Elabscience

Category ELISA Kit
Sensitivity 75.00 pg/mL
Range 125.00—8000 pg/mL

Anti livin antibody, ELISA Kit - MBS733784 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Anti-livin antibody, ELISA Kit - MBS721454 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS741171 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Anti-livin antibody, ELISA Kit - MBS736825 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS736359 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS728191 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS728968 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS742318 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS740553 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Anti-livin antibody, ELISA Kit - MBS731863 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS734692 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Anti-livin antibody, ELISA Kit - MBS741886 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

baculoviral IAP repeat-containing 7, ELISA Kit - MBS9330268 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

BIRC7, ELISA Kit - MBS2516314 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 75pg/mL
Range 125-8000pg/mL

inhibitor of apoptosis (IAP), ELISA Kit - MBS2600450 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

inhibitor of apoptosis (IAP), ELISA Kit - MBS268610 from MyBioSource

Category ELISA Kit
Prices $290.00, $450.00, $1,755.00, $3,150.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

inhibitor of apoptosis (IAP), ELISA Kit - MBS263036 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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