| Gene Symbol |
BIRC7
|
| Entrez Gene |
79444
|
| Alt Symbol |
KIAP, LIVIN, ML-IAP, MLIAP, RNF50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
baculoviral IAP repeat containing 7
|
| Other Description |
RING finger protein 50|baculoviral IAP repeat-containing protein 7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|melanoma inhibitor of apoptosis protein
|
| Swissprots |
Q96CA5 Q9BQV0 Q9HAP7 Q9H2A8
|
| Accessions |
CAC37337 CAC37338 EAW75302 EAW75303 EAW75304 Q96CA5 AF301009 AAG37878 AF311388 AAG33622 AY358835 AAQ89194 AY358836 AAQ89195 AY517497 AAS01729 BC014475 AAH14475 BU737800 DQ893077 ABM84003 DQ896338 ABM87337 NM_022161 NP_071444 NM_139317 NP_647478
|
| Function |
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isof
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17294084}. Cytoplasm {ECO:0000269|PubMed:17294084}. Golgi apparatus {ECO:0000269|PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
|
| Top Pathways |
Apoptosis, Ubiquitin mediated proteolysis, Small cell lung cancer, Toxoplasmosis
|
![Western Blot: Livin Overexpression Lysate (Adult Normal) [NBL1-07988] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Livin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7947_Livin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07988-img0002.jpg)