BIRC7

Gene Symbol	BIRC7
Entrez Gene	79444
Alt Symbol	KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Species	Human
Gene Type	protein-coding
Description	baculoviral IAP repeat containing 7
Other Description	RING finger protein 50|baculoviral IAP repeat-containing protein 7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|melanoma inhibitor of apoptosis protein
Swissprots	Q96CA5 Q9BQV0 Q9HAP7 Q9H2A8
Accessions	CAC37337 CAC37338 EAW75302 EAW75303 EAW75304 Q96CA5 AF301009 AAG37878 AF311388 AAG33622 AY358835 AAQ89194 AY358836 AAQ89195 AY517497 AAS01729 BC014475 AAH14475 BU737800 DQ893077 ABM84003 DQ896338 ABM87337 NM_022161 NP_071444 NM_139317 NP_647478
Function	Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isof
Subcellular Location	Nucleus {ECO:0000269|PubMed:17294084}. Cytoplasm {ECO:0000269|PubMed:17294084}. Golgi apparatus {ECO:0000269|PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Tissue Specificity	Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
Top Pathways	Apoptosis, Ubiquitin mediated proteolysis, Small cell lung cancer, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Livin (D61D1) XP ® Rabbit mAb - 5471 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D61D1

ML-IAP (A-1) - sc-166390 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ML-IAP (E-3) - sc-393237 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ML-IAP (C-12) - sc-33955 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ML-IAP (H-90) - sc-30161 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ML-IAP (C-20) - sc-22964 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ML-IAP (V-20) - sc-22963 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ML-IAP (N-15) - sc-33954 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ML-IAP (4H196) - sc-71592 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Livin antibody - ab97350 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Livin antibody - ab182771 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Livin antibody - ab5393 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Livin antibody - ab77190 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-Livin antibody - ab14558 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Livin antibody [1D12] - ab118026 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D12

Anti-Livin antibody [51.3_2A3] - ab127979 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 51.3_2A3

Anti-Livin antibody [5132A3] - ab174710 from Abcam Host Mouse Clonality Monoclonal Clone 5132A3

Anti-Livin antibody [88C570] - ab11983 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 88C570

Anti-BIRC7 / Livin Antibody (aa264-280) IHC-plus™ - LS-B456 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BIRC7 / Livin Antibody (Glu211) - LS-C177594 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BIRC7 / Livin Antibody (C-Terminus, AP) - LS-C244934 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BIRC7 / Livin Antibody (aa271-298) - LS-C100376 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BIRC7 / Livin Antibody (C-Terminus, APC) - LS-C244935 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BIRC7 / Livin Antibody (C-Terminus, Biotin) - LS-C244936 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BIRC7 / Livin Antibody (clone 88C570) IHC-plus™ - LS-B2018 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 88C570

Search more