Gene Symbol | TMEM30B |
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Entrez Gene | 161291 |
Alt Symbol | CDC50B |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 30B |
Other Description | P4-ATPase flippase complex beta subunit TMEM30B|cell cycle control protein 50B |
Swissprots | Q3MIR4 Q14D00 B3KR84 |
Accessions | EAW80799 Q3MIR4 AK091169 BAG52296 AL080078 BC101726 AAI01727 BC113559 AAI13560 DA431345 DA666826 DB220251 DB237714 NM_001017970 NP_001017970 |
Function | Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. {ECO:0000269|PubMed:20961850, ECO:0000305}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:20961850}; Multi-pass membrane protein {ECO:0000269|PubMed:20961850}. |
Cdc50B CRISPR/Cas9 KO Plasmid (h) - sc-414823 from Santa Cruz Biotechnology
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Cdc50B HDR Plasmid (h) - sc-414823-HDR from Santa Cruz Biotechnology
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Cdc50B Double Nickase Plasmid (h) - sc-414823-NIC from Santa Cruz Biotechnology
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Cdc50B Double Nickase Plasmid (h2) - sc-414823-NIC-2 from Santa Cruz Biotechnology
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Cdc50B CRISPR Activation Plasmid (h) - sc-414823-ACT from Santa Cruz Biotechnology
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Cdc50B CRISPR Activation Plasmid (h2) - sc-414823-ACT-2 from Santa Cruz Biotechnology
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Cdc50B Lentiviral Activation Particles (h) - sc-414823-LAC from Santa Cruz Biotechnology
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Cdc50B Lentiviral Activation Particles (h2) - sc-414823-LAC-2 from Santa Cruz Biotechnology
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Cdc50B siRNA (h) - sc-92313 from Santa Cruz Biotechnology
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Cdc50B shRNA Plasmid (h) - sc-92313-SH from Santa Cruz Biotechnology
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Cdc50B shRNA (h) Lentiviral Particles - sc-92313-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21616 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21616 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11743 from Sigma-Aldrich
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TMEM30B siRNA (Human) - CRJ5922 from Cohesion Biosciences
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TMEM30B - MBS8232434 from MyBioSource
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shRNA set against Human TMEM30B (NM_001017970.2) - SHH430396 from Creative biogene
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shRNA set against Human TMEM30B(NM_001017970.2) - SHL078906 from Creative biogene
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Human TMEM30B siRNA - orb276423 from Biorbyt
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TMEM30B shRNA Plasmid (Human) - CHJ5922 from Cohesion Biosciences
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TMEM30B miRNA 3'UTR clone - MiUTR1H-10528 from Creative biogene
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