| Gene Symbol |
ATP10D
|
| Entrez Gene |
57205
|
| Alt Symbol |
ATPVD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, class V, type 10D
|
| Other Description |
P4-ATPase flippase complex alpha subunit ATP10D|probable phospholipid-transporting ATPase VD|type IV aminophospholipid transporting ATPase
|
| Swissprots |
D6REN2 Q8NC70 Q96SR3 A2RRC8 Q9P241
|
| Accessions |
EAW93036 EAW93037 Q9P241 AB040920 BAA96011 AJ441078 CAD29577 AK027598 BAB55221 AK074930 BAC11299 BC057839 AAH57839 BC131535 AAI31536 XM_005248119 XP_005248176 XM_005248120 XP_005248177 XM_011513722 XP_011512024 XM_011513723 XP_011512025 XR_925154 NM_020453 NP_065186
|
| Function |
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
|
| Tissue Specificity |
Expressed in placenta and, to a lesser extent, in kidney. {ECO:0000269|PubMed:12532265}.
|