Gene Symbol | ATP10D |
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Entrez Gene | 57205 |
Alt Symbol | ATPVD |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, class V, type 10D |
Other Description | P4-ATPase flippase complex alpha subunit ATP10D|probable phospholipid-transporting ATPase VD|type IV aminophospholipid transporting ATPase |
Swissprots | D6REN2 Q8NC70 Q96SR3 A2RRC8 Q9P241 |
Accessions | EAW93036 EAW93037 Q9P241 AB040920 BAA96011 AJ441078 CAD29577 AK027598 BAB55221 AK074930 BAC11299 BC057839 AAH57839 BC131535 AAI31536 XM_005248119 XP_005248176 XM_005248120 XP_005248177 XM_011513722 XP_011512024 XM_011513723 XP_011512025 XR_925154 NM_020453 NP_065186 |
Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B. |
Tissue Specificity | Expressed in placenta and, to a lesser extent, in kidney. {ECO:0000269|PubMed:12532265}. |
ATP10D CRISPR/Cas9 KO Plasmid (h) - sc-412777 from Santa Cruz Biotechnology
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ATP10D HDR Plasmid (h) - sc-412777-HDR from Santa Cruz Biotechnology
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ATP10D Double Nickase Plasmid (h) - sc-412777-NIC from Santa Cruz Biotechnology
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ATP10D Double Nickase Plasmid (h2) - sc-412777-NIC-2 from Santa Cruz Biotechnology
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ATP10D CRISPR Activation Plasmid (h) - sc-412777-ACT from Santa Cruz Biotechnology
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ATP10D CRISPR Activation Plasmid (h2) - sc-412777-ACT-2 from Santa Cruz Biotechnology
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ATP10D Lentiviral Activation Particles (h) - sc-412777-LAC from Santa Cruz Biotechnology
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ATP10D Lentiviral Activation Particles (h2) - sc-412777-LAC-2 from Santa Cruz Biotechnology
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ATP10D siRNA (h) - sc-89171 from Santa Cruz Biotechnology
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ATP10D shRNA Plasmid (h) - sc-89171-SH from Santa Cruz Biotechnology
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ATP10D shRNA (h) Lentiviral Particles - sc-89171-V from Santa Cruz Biotechnology
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ATP10D RNAi - H00057205-R02 from Novus Biologicals
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MISSION® esiRNA - EHU006851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3671 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10958 from Sigma-Aldrich
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ATP10D siRNA (Human) - CRJ1394 from Cohesion Biosciences
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ATP10D - MBS8241231 from MyBioSource
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shRNA set against Human ATP10D (NM_020453.3) - SHH242386 from Creative biogene
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Human ATP10D siRNA - orb271895 from Biorbyt
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ATP10D shRNA Plasmid (Human) - CHJ1394 from Cohesion Biosciences
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