CDC34

Gene Symbol CDC34
Entrez Gene 997
Alt Symbol E2-CDC34, UBC3, UBCH3, UBE2R1
Species Human
Gene Type protein-coding
Description cell division cycle 34
Other Description cell division cycle 34 homolog|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 R1|ubiquitin-conjugating enzyme E2-32 KDA complementing|ubiquitin-conjugating enzyme E2-CDC34|ubiquitin-protein ligase R1
Swissprots P49427 A8K689
Accessions AAT46688 EAW61190 EAW61191 P49427 AK291554 BAF84243 BC002332 BC009850 AAH09850 BC018143 AAH18143 BC023979 AAH23979 BT006659 AAP35305 DQ890738 ABM81664 DQ893910 ABM84836 DQ894652 ABM85578 L22005 AAC37534 XM_005259690 XP_005259747 XM_006722952 XP_006723015 NM_004359 NP_004350
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5- mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of
Subcellular Location Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
Tissue Specificity Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription. {ECO:0000269|PubMed:10373550}.
Top Pathways Ubiquitin mediated proteolysis, Herpes simplex infection

UBC3 Antibody - 4997 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat, CAD and C6 cells using UBC3 Antibody.

Cdc34 (G-11) - sc-166738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc34 (G-11): sc-166738. Western blot analysis of Cdc34 expression in non-transfected: sc-110760 (A) and human Cdc34 transfected: sc-113137 (B) 293 whole cell lysates.

Cdc34 (H-81) - sc-5616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc34 (H-81): sc-5616. Western blot analysis of Cdc34 expression in K-562 (A), A-431 (B), HeLa (C) and HeLa + PMA (D) nuclear extracts.

Cdc34 (H-4) - sc-28381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc34 (H-4): sc-28381. Western blot analysis of Cdc34 expression in non-transfected: sc-110760 (A) and human Cdc34 transfected: sc-113137 (B) 293 whole cell lysates.

Cdc34 (17) - sc-135861 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Cdc34 (17): sc-135861. Western blot analysis of Cdc34 expression in HeLa whole cell lysate.

Cdc34 (A-20) - sc-5226 from Santa Cruz Biotechnology

Host Goat
Clonality Polyclonal
Cdc34 (A-20): sc-5226. Immunofluorescence staining of methanol-fixed K-562 cells showing nuclear staining.

Anti-Cdc34 antibody - ab115644 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Cdc34 antibody - ab90300 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Cdc34 antibody (ab90300) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Cdc34 antibody - ab482 from Abcam

Prices $359.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-Cdc34 antibody - C-terminal - ab200155 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdc34 antibody - C-terminal (ab200155) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extractLane 3 : Jurkat total cell extract

Anti-CDC34 Antibody (clone 14B5) - LS-C19945 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 14B5

Anti-CDC34 Antibody (clone 90.12) - LS-C19947 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 90.12

Anti-CDC34 Antibody - LS-C19954 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-CDC34 Antibody (N-Terminus) - LS-C83531 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CDC34 Antibody (aa148-163) - LS-C312602 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of CDC34 antibody. Lane 1: Rat Testis Tissue Lysate. Lane 2: HELA Cell Lysate. Lane 3: NIH3T3 Cell Lysate. Lane 4: SMMC Cell Lysate. Lane 5: 293T Cell Lysate. Lane 6: A549 Cell Lysate..

Anti-CDC34 Antibody (C-Terminus) - LS-C112299 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CDC34 antibody LS-C112299 Western blot of Fetal Thymus lysate. Antibody concentration 1 ug/ml.

Anti-CDC34 Antibody (Asp163) - LS-C177296 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Cdc34 (D163) pAb in extracts from COLO205 cells treated with Forskolin.

Anti-CDC34 Antibody (aa114-163) - LS-C199807 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Cdc34 antibody in extracts from COLO205 cells treated with Forskolin.

Anti-CDC34 Antibody - LS-C334070 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded mouse brain using CDC34 antibody at dilution of 1:200 (x400 lens).

UbcH3/Cdc34 Antibody (14B5) - NB500-168 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 14B5
Western Blot: Cdc34 Antibody (14B5) [NB500-168] - Sample (30 ug of whole cell lysate) A: A549 B: HCT116 10% SDS PAGE; antibody diluted at 1:1000.

UbcH3/Cdc34 Antibody - NBP1-84946 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UbcH3/Cdc34 Antibody [NBP1-84946] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-112

UbcH3/Cdc34 Antibody - A-610 from Novus Biologicals

Prices $159.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

UbcH3/Cdc34 Antibody (90.12) - NB500-110 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 90.12
Western Blot: Cdc34 Antibody (90.12) [NB500-110] - Detection of human CDC34 protein in DU145 whole cell lysate.

UbcH3/Cdc34 Antibody - NBP1-32153 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UbcH3/Cdc34 Antibody [NBP1-32153] - Sample (30ug whole cell lysate) A:Raji 12% SDS PAGE, antibody diluted at 1:1000.

UbcH3/Cdc34 Antibody - H00000997-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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