CDC34

Gene Symbol	CDC34
Entrez Gene	997
Alt Symbol	E2-CDC34, UBC3, UBCH3, UBE2R1
Species	Human
Gene Type	protein-coding
Description	cell division cycle 34
Other Description	cell division cycle 34 homolog|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 R1|ubiquitin-conjugating enzyme E2-32 KDA complementing|ubiquitin-conjugating enzyme E2-CDC34|ubiquitin-protein ligase R1
Swissprots	P49427 A8K689
Accessions	AAT46688 EAW61190 EAW61191 P49427 AK291554 BAF84243 BC002332 BC009850 AAH09850 BC018143 AAH18143 BC023979 AAH23979 BT006659 AAP35305 DQ890738 ABM81664 DQ893910 ABM84836 DQ894652 ABM85578 L22005 AAC37534 XM_005259690 XP_005259747 XM_006722952 XP_006723015 NM_004359 NP_004350
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5- mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of
Subcellular Location	Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
Tissue Specificity	Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription. {ECO:0000269|PubMed:10373550}.
Top Pathways	Ubiquitin mediated proteolysis, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cdc34 full length protein - ab151828 from Abcam Category Protein Prices $188.00 Sizes 20 µg Source E. coli Species Human

Human Cdc34 full length protein - ab127393 from Abcam Category Protein Source E. coli Species Human

Human Cdc34 full length protein - ab58720 from Abcam Category Protein Prices $320.00 Sizes 50 µg Source E. coli Species Human

Human Cdc34 full length protein - ab111450 from Abcam Category Protein Prices $518.00 Sizes 100 µg Source E. coli Species Human

CDC34 Antibody Blocking Peptide - LS-E10497 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UbcH3/Cdc34 Recombinant Protein - H00000997-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UbcH3/Cdc34 Protein - NBP1-99923 from Novus Biologicals Category Protein Prices $350.00 Sizes 100 µg Source E. coli Species Human

Recombinant Human UbcH3/Cdc34 Protein - NBP1-48388 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

UbcH3/Cdc34 Peptide - P0890 from Novus Biologicals Category Peptide Species Human

UbcH3/Cdc34 Peptide - P0889 from Novus Biologicals Category Peptide Species Human

CDC34-Antibody-C-term-Blocking-Peptide - BP2116b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDC34-Antibody-N-term-Blocking-Peptide - BP2116a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-UbcH3/Cdc34, CF - E2-610-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal Met and 6-His tag

Recombinant Human His6-UbcH3/Cdc34, CF - E2-610-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal Met and 6-His tag

CDC34 Protein (OPPA01522) - OPPA01522 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human UBE2R1 protein - orb223937 from Biorbyt Category Protein Prices $221.00, $357.00, $519.00 Sizes 5 μg, 20 μg, 100 μg Species Human

Cell Division Cycle 34 His tag protein - orb90055 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human CDC34 protein - orb107694 from Biorbyt Category Protein Prices $221.00, $357.00, $425.00, $629.00 Sizes 10 μg, 50 μg, 100 μg, 250 μg Source E.coli

CDC34 Blocking Peptide - 33R-9159 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CDC34 protein (His tag) - 80R-1472 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

UBCH3 protein (His tag) - 80R-2538 from Fitzgerald Category Protein Prices $425.00 Sizes 100 µg Source E.coli Species Human

CDC34 Blocking Peptide - abx062390 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

CDC34 (1-236, His-tag) - AR09648PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CDC34 (1-236, His-tag) - AR09648PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CDC34 - H00000997-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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