| Gene Symbol |
CDC34
|
| Entrez Gene |
997
|
| Alt Symbol |
E2-CDC34, UBC3, UBCH3, UBE2R1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle 34
|
| Other Description |
cell division cycle 34 homolog|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 R1|ubiquitin-conjugating enzyme E2-32 KDA complementing|ubiquitin-conjugating enzyme E2-CDC34|ubiquitin-protein ligase R1
|
| Swissprots |
P49427 A8K689
|
| Accessions |
AAT46688 EAW61190 EAW61191 P49427 AK291554 BAF84243 BC002332 BC009850 AAH09850 BC018143 AAH18143 BC023979 AAH23979 BT006659 AAP35305 DQ890738 ABM81664 DQ893910 ABM84836 DQ894652 ABM85578 L22005 AAC37534 XM_005259690 XP_005259747 XM_006722952 XP_006723015 NM_004359 NP_004350
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5- mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
|
| Tissue Specificity |
Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription. {ECO:0000269|PubMed:10373550}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Herpes simplex infection
|