MRVI1

Gene Symbol	MRVI1
Entrez Gene	10335
Alt Symbol	IRAG, JAW1L
Species	Human
Gene Type	protein-coding
Description	murine retrovirus integration site 1 homolog
Other Description	IP3R-associated cGMP kinase substrate|JAW1-related protein MRVI1|inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate|inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate|protein MRVI1
Swissprots	B7Z9A3 J3KQZ7 F5H6A1 E9PQY6 Q17S00 B7Z6I2 Q9Y6F6 B7Z3T4 Q9UNY1
Accessions	EAW68559 EAW68560 EAW68561 EAW68562 EAW68563 Q9Y6F6 AF081249 AAD25922 AF081250 AAD25923 AK002039 AK127209 AK296336 BAH12320 AK300358 BAH13268 AK301296 BAH13451 AK304702 BAH14239 AL044056 AL117524 AL603309 AL832178 BC117127 AAI17128 DA127310 DA163499 DA185715 DA797538 DB132030 DB167290 DB445355 DC422754 HQ258320 ADR83074 NM_001098579 NP_001092049 NM_001100163 NP_001093633 NM_001100167 NP_001093637 NM_001206880 NP_001193809 NM_001206881 NP_001193810 NM_130385 NP_569056
Function	Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269|PubMed:14729908}.
Subcellular Location	Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines. {ECO:0000269|PubMed:10321731, ECO:0000269|PubMed:14729908}.
Top Pathways	Vascular smooth muscle contraction, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MRVI1 (C-17) - sc-10958 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MRVI1 (H-108) - sc-366830 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MRVI1a (N-19) - sc-10953 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MRVI1a (P-15) - sc-10954 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-MRVI1 antibody - ab151309 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MRVI1 Antibody (aa51-100) - LS-C205780 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

IRAG Antibody - NBP2-16987 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

IRAG Antibody - NBP1-87877 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MRVI1 antibody produced in rabbit - SAB2700716 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MRVI1 antibody produced in rabbit - HPA008704 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MRVI1 Antibody - N-terminal region (ARP50282_P050) - ARP50282_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MRVI1 antibody - GTX123277 from GeneTex Prices $119.00 Sizes 25 μl Host Rabbit Clonality Polyclonal

MRVI1 antibody (FITC) - orb189623 from Biorbyt Prices $315.00 Sizes 100 μg Host Rabbit Clonality Polyclonal

MRVI1 Antibody - abx037205 from Abbexa Host Rabbit Clonality Polyclonal

MRVI1 / IRAG antibody - H00010335-B01P from Acris Antibodies Prices $1,530.00 Sizes 500 µg Host Mouse Clonality Polyclonal

MRVI1 Antibody - E307552 from Enogene Prices $275.00 Sizes 200 µl Host Rabbit

Anti-MRVI1 (aa 404-547) polyclonal antibody - DPABH-03411 from Creative Diagnostics Host Rabbit Clonality Polyclonal

MRVI1 Polyclonal Antibody - PA5-32111 from Thermo Fisher Scientific Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MRVI1 - MBS273765 from MyBioSource Prices $360.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MRVI1, Polyclonal Antibody - MBS8500916 from MyBioSource Prices $330.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

MRVI1 / IRAG antibody - TA342098 from Acris Antibodies Prices $325.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

MRVI1 antibody - orb185309 from Biorbyt Prices $60.00, $128.00, $255.00, $340.00 Sizes 5 μg (Trial Size), 20 μg (Trial Size), 100 μg, 200 μg Host Rabbit Clonality Polyclonal Clone $155

ANTI-MRVI1 (N-TERM) antibody produced in rabbit - SAB1304788 from Sigma-Aldrich Prices $336.50 Sizes 400 µl Clonality Polyclonal

Anti-MRVI1 Antibody A09123 - A09123 from Boster Bio Prices $299.00 Sizes 1 Host Rabbit Clonality Polyclonal

MRVI1 Antibody - N-terminal region : Biotin (ARP50282_P050-Biotin) - ARP50282_P050-Biotin from Aviva Systems Biology Host Rabbit Clonality Polyclonal

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