| Gene Symbol |
MRVI1
|
| Entrez Gene |
10335
|
| Alt Symbol |
IRAG, JAW1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
murine retrovirus integration site 1 homolog
|
| Other Description |
IP3R-associated cGMP kinase substrate|JAW1-related protein MRVI1|inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate|inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate|protein MRVI1
|
| Swissprots |
B7Z9A3 J3KQZ7 F5H6A1 E9PQY6 Q17S00 B7Z6I2 Q9Y6F6 B7Z3T4 Q9UNY1
|
| Accessions |
EAW68559 EAW68560 EAW68561 EAW68562 EAW68563 Q9Y6F6 AF081249 AAD25922 AF081250 AAD25923 AK002039 AK127209 AK296336 BAH12320 AK300358 BAH13268 AK301296 BAH13451 AK304702 BAH14239 AL044056 AL117524 AL603309 AL832178 BC117127 AAI17128 DA127310 DA163499 DA185715 DA797538 DB132030 DB167290 DB445355 DC422754 HQ258320 ADR83074 NM_001098579 NP_001092049 NM_001100163 NP_001093633 NM_001100167 NP_001093637 NM_001206880 NP_001193809 NM_001206881 NP_001193810 NM_130385 NP_569056
|
| Function |
Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269|PubMed:14729908}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines. {ECO:0000269|PubMed:10321731, ECO:0000269|PubMed:14729908}.
|
| Top Pathways |
Vascular smooth muscle contraction, cGMP-PKG signaling pathway
|
