MRVI1

Gene Symbol MRVI1
Entrez Gene 10335
Alt Symbol IRAG, JAW1L
Species Human
Gene Type protein-coding
Description murine retrovirus integration site 1 homolog
Other Description IP3R-associated cGMP kinase substrate|JAW1-related protein MRVI1|inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate|inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate|protein MRVI1
Swissprots B7Z9A3 J3KQZ7 F5H6A1 E9PQY6 Q17S00 B7Z6I2 Q9Y6F6 B7Z3T4 Q9UNY1
Accessions EAW68559 EAW68560 EAW68561 EAW68562 EAW68563 Q9Y6F6 AF081249 AAD25922 AF081250 AAD25923 AK002039 AK127209 AK296336 BAH12320 AK300358 BAH13268 AK301296 BAH13451 AK304702 BAH14239 AL044056 AL117524 AL603309 AL832178 BC117127 AAI17128 DA127310 DA163499 DA185715 DA797538 DB132030 DB167290 DB445355 DC422754 HQ258320 ADR83074 NM_001098579 NP_001092049 NM_001100163 NP_001093633 NM_001100167 NP_001093637 NM_001206880 NP_001193809 NM_001206881 NP_001193810 NM_130385 NP_569056
Function Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269|PubMed:14729908}.
Subcellular Location Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines. {ECO:0000269|PubMed:10321731, ECO:0000269|PubMed:14729908}.
Top Pathways Vascular smooth muscle contraction, cGMP-PKG signaling pathway

MRVI1 CRISPR/Cas9 KO Plasmid (h) - sc-411458 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 HDR Plasmid (h) - sc-411458-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 Double Nickase Plasmid (h) - sc-411458-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 Double Nickase Plasmid (h2) - sc-411458-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 CRISPR Activation Plasmid (h) - sc-411458-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 CRISPR Activation Plasmid (h2) - sc-411458-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 Lentiviral Activation Particles (h) - sc-411458-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 Lentiviral Activation Particles (h2) - sc-411458-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRVI1 siRNA (h) - sc-42928 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRVI1 shRNA Plasmid (h) - sc-42928-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRVI1 shRNA (h) Lentiviral Particles - sc-42928-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRVI1a siRNA (h) - sc-42930 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRVI1a shRNA Plasmid (h) - sc-42930-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRVI1a shRNA (h) Lentiviral Particles - sc-42930-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU093831 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14626 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14626 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MRVI1 siRNA (Human) - CRH7007 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MRVI1 (NM_001098579.2) - SHH345424 from Creative biogene

Category siRNA
Species Reactivities Human

Human MRVI1 siRNA - orb267509 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MRVI1 shRNA Plasmid (Human) - CHH7007 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MRVI1 miRNA 3'UTR clone - MiUTR4H-TG05682 from Creative biogene

Species Reactivities Human
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