KLRB1

Gene Symbol KLRB1
Entrez Gene 3820
Alt Symbol CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A
Species Human
Gene Type protein-coding
Description killer cell lectin-like receptor subfamily B, member 1
Other Description C-type lectin domain family 5 member B|killer cell lectin-like receptor subfamily B member 1|natural killer cell surface protein P1A
Swissprots Q24K24 Q12918
Accessions EAW96108 Q12918 AK292022 BAF84711 BC027885 BC113997 AAI13998 BC114516 AAI14517 BF432813 U11276 AAA21605 NM_002258 NP_002249
Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. {ECO:0000269|PubMed:16455998, ECO:0000269|PubMed:16925668, ECO:0000269|PubMed:8077657}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. {ECO:0000269|PubMed:12100027, ECO:0000269|PubMed:8077657}.
Top Pathways Malaria

CD161 (N-20) - sc-17028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD161 (N-20): sc-17028. Western blot analysis of CD161 expression in NK-92 (A) and human PBL (B) whole cell lysates.

CD161 (C-16) - sc-70148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CD161 (HP-3G10) - sc-69891 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

CD161 (B199.2) - sc-58963 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CD161 (B199.2): sc-58963. Indirect FCM analysis of human peripheral blood leukocytes stained with CD161 (B199.2), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-3879.

Anti-CD161 antibody - ab197979 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD161 antibody (ab197979) at 1/300 dilutionLane 1 : Mouse kidney lysateLane 2 : Human fetal liver tissue lysateLysates/proteins at 40 µg per lane.

Anti-CD161 antibody - ab76528 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD161 antibody (ab76528) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD161 antibody - ab190637 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD161 antibody (ab190637) at 1/500 dilution + K562 cell extract at 30 µg

Anti-CD161 antibody [B199.2] - ab23624 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B199.2

Anti-CD161 antibody [EP7169] - ab137059 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP7169
All lanes : Anti-CD161 antibody [EP7169] (ab137059) at 1/1000 dilutionLane 1 : Human small intestine tissue lysateLane 2 : HuT-78 cell lysateLane 3 : THP1 cell lysateLane 4 : Caco 2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Anti-CD161 antibody [HP-3G10] - ab188409 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone HP-3G10

Anti-CD161 antibody [HP-3G10] (Phycoerythrin) - ab188416 from Abcam

Prices $370.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone HP-3G10

Anti-CD161 antibody [IMG14F1F11] - ab138702 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMG14F1F11
Anti-CD161 antibody [IMG14F1F11] (ab138702) at 1 µg/ml + Recombinant CD161 protein

Anti-KLRB1 / CD161 Antibody - LS-C14351 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (Biotin) - LS-C14353 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (clone B199.2, PE) - LS-C14358 from LifeSpan Bioscience

Prices $455.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone B199.2

Anti-KLRB1 / CD161 Antibody (Azide-free) - LS-C14352 from LifeSpan Bioscience

Prices $845.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (clone B199.2) - LS-C14357 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone B199.2

Anti-KLRB1 / CD161 Antibody (FITC) - LS-C14360 from LifeSpan Bioscience

Prices $650.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (clone B199.2, Biotin) - LS-C35855 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B199.2

Anti-KLRB1 / CD161 Antibody (FITC) - LS-C43594 from LifeSpan Bioscience

Prices $265.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (Biotin) - LS-C43592 from LifeSpan Bioscience

Prices $280.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (clone 10/78, RPE) - LS-C43597 from LifeSpan Bioscience

Prices $445.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 10/78

Anti-KLRB1 / CD161 Antibody (FITC) - LS-C43593 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KLRB1 / CD161 Antibody (clone 10/78) - LS-C43596 from LifeSpan Bioscience

Prices $225.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10/78

Anti-KLRB1 / CD161 Antibody (FITC) - LS-C43595 from LifeSpan Bioscience

Prices $515.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
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