| Gene Symbol | KLRB1 |
|---|---|
| Entrez Gene | 3820 |
| Alt Symbol | CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A |
| Species | Human |
| Gene Type | protein-coding |
| Description | killer cell lectin-like receptor subfamily B, member 1 |
| Other Description | C-type lectin domain family 5 member B|killer cell lectin-like receptor subfamily B member 1|natural killer cell surface protein P1A |
| Swissprots | Q24K24 Q12918 |
| Accessions | EAW96108 Q12918 AK292022 BAF84711 BC027885 BC113997 AAI13998 BC114516 AAI14517 BF432813 U11276 AAA21605 NM_002258 NP_002249 |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. {ECO:0000269|PubMed:16455998, ECO:0000269|PubMed:16925668, ECO:0000269|PubMed:8077657}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. {ECO:0000269|PubMed:12100027, ECO:0000269|PubMed:8077657}. |
| Top Pathways | Malaria |
CD161 CRISPR/Cas9 KO Plasmid (h) - sc-405895 from Santa Cruz Biotechnology
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CD161 HDR Plasmid (h) - sc-405895-HDR from Santa Cruz Biotechnology
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CD161 Double Nickase Plasmid (h) - sc-405895-NIC from Santa Cruz Biotechnology
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CD161 Double Nickase Plasmid (h2) - sc-405895-NIC-2 from Santa Cruz Biotechnology
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CD161 CRISPR Activation Plasmid (h) - sc-405895-ACT from Santa Cruz Biotechnology
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CD161 CRISPR Activation Plasmid (h2) - sc-405895-ACT-2 from Santa Cruz Biotechnology
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CD161 Lentiviral Activation Particles (h) - sc-405895-LAC from Santa Cruz Biotechnology
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CD161 Lentiviral Activation Particles (h2) - sc-405895-LAC-2 from Santa Cruz Biotechnology
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CD161 siRNA (h) - sc-42935 from Santa Cruz Biotechnology
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CD161 shRNA Plasmid (h) - sc-42935-SH from Santa Cruz Biotechnology
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CD161 shRNA (h) Lentiviral Particles - sc-42935-V from Santa Cruz Biotechnology
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CD161 RNAi - H00003820-R02 from Novus Biologicals
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MISSION® esiRNA - EHU045711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11320 from Sigma-Aldrich
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KLRB1 siRNA (Human) - CRH2588 from Cohesion Biosciences
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CD161 CRISPR/Cas9 KO Plasmid (h2) - sc-405895-KO-2 from Santa Cruz Biotechnology
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CD161 HDR Plasmid (h2) - sc-405895-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KLRB1(NM_002258.2) - SHR008238 from Creative biogene
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Human KLRB1 siRNA - orb263090 from Biorbyt
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KLRB1 shRNA Plasmid (Human) - CHH2588 from Cohesion Biosciences
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KLRB1 miRNA 3'UTR clone - MiUTR1H-05411 from Creative biogene
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