KLRB1

Gene Symbol	KLRB1
Entrez Gene	3820
Alt Symbol	CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A
Species	Human
Gene Type	protein-coding
Description	killer cell lectin-like receptor subfamily B, member 1
Other Description	C-type lectin domain family 5 member B|killer cell lectin-like receptor subfamily B member 1|natural killer cell surface protein P1A
Swissprots	Q24K24 Q12918
Accessions	EAW96108 Q12918 AK292022 BAF84711 BC027885 BC113997 AAI13998 BC114516 AAI14517 BF432813 U11276 AAA21605 NM_002258 NP_002249
Function	Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. {ECO:0000269|PubMed:16455998, ECO:0000269|PubMed:16925668, ECO:0000269|PubMed:8077657}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. {ECO:0000269|PubMed:12100027, ECO:0000269|PubMed:8077657}.
Top Pathways	Malaria

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD161 peptide - ab87450 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD161 protein fragment - ab131668 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

CD161 Partial Recombinant Protein - H00003820-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CD161 Protein - NBP2-23169 from Novus Biologicals Category Protein Prices $299.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human CD161 Fc Chimera, CF - 7448-CD-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human KLRB1 protein - orb168703 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

NKR peptide - orb73026 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg Source This peptide is homologous with the Human, Mouse, Rat, Guinea Pig, Pig, Dog, Horse, Rabbit, Cow and Chicken sequences of NKR.

Human KLRB1 Protein - abx067655 from Abbexa Category Protein Source E.coli Species Human

CD161 / KLRB1 (67-225, His-tag) - AR50502PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD161 / KLRB1 (67-225, His-tag) - AR50502PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD161 / KLRB1 - H00003820-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD161 / KLRB1 - H00003820-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD161 / KLRB1 - P5859 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Human

KLRB1, 67-225aa, Human, His tag, E.coli - 01-P1678 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KLRB1,CD161 fusion protein - ag17900 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

KLRB1,CD161 fusion protein - ag17816 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Protein - BP002471-PRO-1189 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

KLRB1, 67-225aa, Recombinant Protein - GWB-P0360I from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) - RPA986Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

KLRB1 - PAT-80568-1 from Nordic BioSite Category Protein Species Human

KLRB1 - PAT-80568-2 from Nordic BioSite Category Protein Species Human

Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) - RPA986Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Killer cell lectin-like receptor subfamily B member 1(KLRB1) - CSB-YP621524HU CSB-EP621524HU CSB-BP621524HU CSB-MP621524HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KLRB1, 67-225aa, Human, His tag, E.coli (Denatured) - ATGP1678 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KLRB1, human recombinant - 7352-100 from Biovision Category Protein Prices $295.00 Sizes 100 μg Source E. coli Species Human

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