| Gene Symbol |
PPP1R14A
|
| Entrez Gene |
94274
|
| Alt Symbol |
CPI-17, CPI17, PPP1INL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory (inhibitor) subunit 14A
|
| Other Description |
17 kDa PKC-potentiated inhibitory protein of PP1|17-KDa protein|17-kDa PKC-potentiated inhibitory protein of PP1|PKC-potentiated inhibitory protein of PP1|protein kinase C-potentiated inhibitor protein of 17 kDa|protein phosphatase 1 regulatory subunit 14A
|
| Swissprots |
Q96A00 Q96S54 Q7Z4X7
|
| Accessions |
AAL24445 EAW56764 EAW56765 Q96A00 AB056508 BAB62502 AB056509 BAB62503 AF123763 AAP97242 AY050670 AAL25828 BC021089 AAH21089 DQ892130 ABM83056 DQ895324 ABM86250 ES314242 NM_001243947 NP_001230876 NM_033256 NP_150281
|
| Function |
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. {ECO:0000269|PubMed:11467857}.
|
| Top Pathways |
Vascular smooth muscle contraction
|
![Western Blot: CPI17 alpha Overexpression Lysate (Adult Normal) [NBL1-14675] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CPI17 alpha.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5121_CPI17%2520alpha%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14675-img0002.jpg)