Gene Symbol | PPP1R14A |
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Entrez Gene | 94274 |
Alt Symbol | CPI-17, CPI17, PPP1INL |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Other Description | 17 kDa PKC-potentiated inhibitory protein of PP1|17-KDa protein|17-kDa PKC-potentiated inhibitory protein of PP1|PKC-potentiated inhibitory protein of PP1|protein kinase C-potentiated inhibitor protein of 17 kDa|protein phosphatase 1 regulatory subunit 14A |
Swissprots | Q96A00 Q96S54 Q7Z4X7 |
Accessions | AAL24445 EAW56764 EAW56765 Q96A00 AB056508 BAB62502 AB056509 BAB62503 AF123763 AAP97242 AY050670 AAL25828 BC021089 AAH21089 DQ892130 ABM83056 DQ895324 ABM86250 ES314242 NM_001243947 NP_001230876 NM_033256 NP_150281 |
Function | Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. {ECO:0000269|PubMed:11467857}. |
Top Pathways | Vascular smooth muscle contraction |
CPI-17 CRISPR/Cas9 KO Plasmid (h) - sc-401966 from Santa Cruz Biotechnology
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CPI-17 HDR Plasmid (h) - sc-401966-HDR from Santa Cruz Biotechnology
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CPI-17 Double Nickase Plasmid (h) - sc-401966-NIC from Santa Cruz Biotechnology
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CPI-17 Double Nickase Plasmid (h2) - sc-401966-NIC-2 from Santa Cruz Biotechnology
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CPI-17 CRISPR Activation Plasmid (h) - sc-401966-ACT from Santa Cruz Biotechnology
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CPI-17 CRISPR Activation Plasmid (h2) - sc-401966-ACT-2 from Santa Cruz Biotechnology
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CPI-17 Lentiviral Activation Particles (h) - sc-401966-LAC from Santa Cruz Biotechnology
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CPI-17 Lentiviral Activation Particles (h2) - sc-401966-LAC-2 from Santa Cruz Biotechnology
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CPI-17 siRNA (h) - sc-40423 from Santa Cruz Biotechnology
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CPI-17 shRNA Plasmid (h) - sc-40423-SH from Santa Cruz Biotechnology
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CPI-17 shRNA (h) Lentiviral Particles - sc-40423-V from Santa Cruz Biotechnology
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CPI17 alpha RNAi - H00094274-R01 from Novus Biologicals
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MISSION® esiRNA - EHU149561 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0542 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0541 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0543 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17264 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17264 from Sigma-Aldrich
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PPP1R14A siRNA (Human) - CRJ4265 from Cohesion Biosciences
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shRNA set against Human PPP1R14A (NM_033256.2) - SHH381064 from Creative biogene
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Human PPP1R14A siRNA - orb274766 from Biorbyt
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PPP1R14A shRNA Plasmid (Human) - CHJ4265 from Cohesion Biosciences
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PPP1R14A miRNA 3'UTR clone - MiUTR3H-09798 from Creative biogene
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