| Gene Symbol |
HIST1H2BL
|
| Entrez Gene |
8340
|
| Alt Symbol |
H2B/c, H2BFC, dJ97D16.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2bl
|
| Other Description |
H2B histone family, member C|histone 1, H2bl|histone H2B type 1-L|histone H2B.c
|
| Swissprots |
B2R5A3 Q99880 Q52LW9
|
| Accessions |
AAN06695 CAB06035 EAX03106 Q99880 AK312114 BAG35050 BC093759 BC093761 EU446971 ABZ92500 NM_003519 NP_003510
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|
![Western Blot: HIST1H2BL Overexpression Lysate (Adult Normal) [NBL1-11564] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HIST1H2BL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2729_HIST1H2BL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11564-img0002.jpg)