Gene Symbol | CYP4F3 |
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Entrez Gene | 4051 |
Alt Symbol | CPF3, CYP4F, LTB4H |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 4, subfamily F, polypeptide 3 |
Other Description | 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF3|cytochrome P-450|cytochrome P450 4F3|cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)|cytochrome P450-LTB-omega|docosahexaenoic acid omega-hydroxylase CYP4F3|leukotriene B4 omega hydroxylase|leukotriene-B(4) 20-monooxygenase 2|leukotriene-B(4) omega-hydroxylase 2|leukotriene-B4 20-monooxygenase |
Swissprots | O60634 Q5U740 B7Z8Z3 Q08477 |
Accessions | AAV40834 BAA25991 EAW84488 EAW84489 EAW84490 EAW84491 Q08477 AB002454 BAA25990 AF054821 AAC08589 AK296761 BAH12428 AK296802 BAH12435 AK298675 BAH12844 AK303477 BAH13972 AK304200 BAH14129 AK316136 BAH14507 BC136299 AAI36300 D12620 BAA02144 D12621 BAA02145 DB184202 XM_005259911 XP_005259968 XM_011528014 XP_011526316 NM_000896 NP_000887 NM_001199208 NP_001186137 NM_001199209 NP_001186138 |
Function | Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:8486631}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract. {ECO:0000269|PubMed:11461919}. |
Top Pathways | Arachidonic acid metabolism |
Anti-CYP4F3 antibody - ab98028 from Abcam
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Anti-CYP4F3 antibody - ab76613 from Abcam
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Anti-CYP4F3 antibody - N-terminal - ab175958 from Abcam
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Anti-CYP4F / CYP4F3 Antibody (aa35-84) - LS-C107669 from LifeSpan Bioscience
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Anti-CYP4F / CYP4F3 Antibody (aa86-115) - LS-C167241 from LifeSpan Bioscience
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Anti-CYP4F / CYP4F3 Antibody (clone 4E11) - LS-C197628 from LifeSpan Bioscience
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CYP4F3 Antibody - NBP1-69678 from Novus Biologicals
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CYP4F3 Antibody - H00004051-A01 from Novus Biologicals
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ANTI-CYP4F3(N-TERMINAL) antibody produced in rabbit - SAB1306976 from Sigma-Aldrich
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Monoclonal Anti-CYP4F3 antibody produced in mouse - SAB1402838 from Sigma-Aldrich
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Anti-CYP4F3, (N-terminal) antibody produced in rabbit - SAB2104860 from Sigma-Aldrich
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CYP4F3 antibody - N-terminal region (ARP41823_P050) - ARP41823_P050 from Aviva Systems Biology
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CYP4F3-Antibody-N-term - AP8646a from Abgent, a WuXi AppTec company
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CYP4F3 Antibody - N-terminal region (OAAB05240) - OAAB05240 from Aviva Systems Biology
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CYP4F3 antibody, N-term - GTX81119 from GeneTex
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CYP4F3 antibody, N-term - GTX47110 from GeneTex
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CYP4F3 antibody - 70R-7504 from Fitzgerald
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CYP4F3 antibody (FITC) - orb187166 from Biorbyt
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Cytochrome p450 antibody - 20R-1445 from Fitzgerald
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CYP1A1 antibody - 20R-CR044 from Fitzgerald
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CYP2C8 + CYP2C9 + CYP2C19 antibody - 20R-CR048 from Fitzgerald
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CYP4F3 Antibody - abx034043 from Abbexa
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CYP4F3 antibody - 19701-1-AP from Acris Antibodies
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CYP4F3 (N-term) antibody - AP17978PU-N from Acris Antibodies
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CYP4F3 antibody - H00004051-A01 from Acris Antibodies
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