Gene Symbol | CLINT1 |
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Entrez Gene | 9685 |
Alt Symbol | CLINT, ENTH, EPN4, EPNR |
Species | Human |
Gene Type | protein-coding |
Description | clathrin interactor 1 |
Other Description | clathrin interacting protein localized in the trans-Golgi region|enthoprotin|epsin 4|epsin-related protein|epsinR |
Swissprots | Q96E05 Q8NAF1 D3DQJ6 B7Z6F8 Q14677 |
Accessions | CCQ43453 EAW61585 EAW61586 EAW61587 EAW61588 Q14677 AF434813 AAL30768 AK092765 BAC03971 AK128594 AK300257 BAH13244 AL529948 AL833548 BC004467 AAH04467 BC013091 AAH13091 BC030264 BI461076 BK000414 DAA00062 BP246338 D79993 BAA11488 XM_011534701 XP_011533003 XM_011534702 XP_011533004 XM_011534703 XP_011533005 NM_001195555 NP_001182484 NM_001195556 NP_001182485 NM_014666 NP_055481 |
Function | Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network. |
Tissue Specificity | Ubiquitously expressed at low to intermediate levels. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
epsin 4 CRISPR/Cas9 KO Plasmid (h) - sc-417926 from Santa Cruz Biotechnology
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epsin 4 HDR Plasmid (h) - sc-417926-HDR from Santa Cruz Biotechnology
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epsin 4 Double Nickase Plasmid (h) - sc-417926-NIC from Santa Cruz Biotechnology
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epsin 4 Double Nickase Plasmid (h2) - sc-417926-NIC-2 from Santa Cruz Biotechnology
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epsin 4 CRISPR Activation Plasmid (h) - sc-417926-ACT from Santa Cruz Biotechnology
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epsin 4 CRISPR Activation Plasmid (h2) - sc-417926-ACT-2 from Santa Cruz Biotechnology
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epsin 4 Lentiviral Activation Particles (h) - sc-417926-LAC from Santa Cruz Biotechnology
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epsin 4 Lentiviral Activation Particles (h2) - sc-417926-LAC-2 from Santa Cruz Biotechnology
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epsin 4 siRNA (h) - sc-105334 from Santa Cruz Biotechnology
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epsin 4 shRNA Plasmid (h) - sc-105334-SH from Santa Cruz Biotechnology
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epsin 4 shRNA (h) Lentiviral Particles - sc-105334-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU010871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6234 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6234 from Sigma-Aldrich
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CLINT1 siRNA (Human) - CRH6457 from Cohesion Biosciences
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CLINT1 - MBS8240148 from MyBioSource
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shRNA set against Human CLINT1 (NM_014666.3) - SHH265345 from Creative biogene
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Human CLINT1 siRNA - orb266959 from Biorbyt
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CLINT1 shRNA Plasmid (Human) - CHH6457 from Cohesion Biosciences
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CLINT1 miRNA 3'UTR clone - MiUTR3H-09096 from Creative biogene
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