EXOSC8

Gene Symbol	EXOSC8
Entrez Gene	11340
Alt Symbol	CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9
Species	Human
Gene Type	protein-coding
Description	exosome component 8
Other Description	CBP-interacting protein 3|OIP-2|Opa interacting protein 2|exosome complex component RRP43|exosome complex exonuclease RRP43|opa-interacting protein 2|ribosomal RNA-processing protein 43
Swissprots	Q5TBA5 Q96B26 O43480
Accessions	EAX08579 EAX08580 EAX08581 Q96B26 AF025438 AAC39558 AF279901 AK096810 AK126602 AL050353 CAI46226 BC020773 AAH20773 BM697343 BU687776 DQ893134 ABM84060 DQ896414 ABM87413 XM_006719763 XP_006719826 XR_429212 XR_941480 NM_181503 NP_852480
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EXOSC8 (N-16) - sc-84108 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

EXOSC8 (P-17) - sc-84109 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

EXOSC8 (H-142) - sc-292860 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EXOSC8 (2336C2b) - sc-81561 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

EXOSC8 (H-8) - sc-393027 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-EXOSC8 antibody - ab187905 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC8 antibody - ab151584 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC8 antibody - ab82290 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC8 antibody [2336C2b] - ab58879 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2336C2b

Anti-EXOSC8 Antibody - LS-C65798 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-EXOSC8 Antibody (clone 2336C2b) - LS-C184596 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2336C2b

Anti-EXOSC8 Antibody (clone 2336C2b) - LS-C342628 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2336C2b

Anti-EXOSC8 Antibody (aa243-276) - LS-C97265 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC8 Antibody (clone 1G5) - LS-C133691 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1G5

Exosome component 8 Antibody (1G5) - H00011340-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1G5

Exosome component 8 Antibody - NBP2-14953 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Exosome component 8 Antibody (4B3) - H00011340-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4B3

Anti-EXOSC8 antibody produced in rabbit - HPA043942 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-EXOSC8, (C-terminal) antibody produced in mouse - SAB1404932 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4B3

Anti-EXOSC8 antibody produced in rabbit - HPA039702 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC8 (7-18) antibody produced in rabbit - SAB1105902 from Sigma-Aldrich Prices $279.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-EXOSC8 antibody produced in mouse - WH0011340M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1G5

EXOSC8 Antibody - C-terminal region (OAAB01480) - OAAB01480 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

EXOSC8-Antibody-C-term - AP2783b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

EXOSC8-Antibody-monoclonal-M01 - AT1969a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1G5

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