EXOSC8

Gene Symbol	EXOSC8
Entrez Gene	11340
Alt Symbol	CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9
Species	Human
Gene Type	protein-coding
Description	exosome component 8
Other Description	CBP-interacting protein 3|OIP-2|Opa interacting protein 2|exosome complex component RRP43|exosome complex exonuclease RRP43|opa-interacting protein 2|ribosomal RNA-processing protein 43
Swissprots	Q5TBA5 Q96B26 O43480
Accessions	EAX08579 EAX08580 EAX08581 Q96B26 AF025438 AAC39558 AF279901 AK096810 AK126602 AL050353 CAI46226 BC020773 AAH20773 BM697343 BU687776 DQ893134 ABM84060 DQ896414 ABM87413 XM_006719763 XP_006719826 XR_429212 XR_941480 NM_181503 NP_852480
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC8 full length protein - ab161419 from Abcam Category Protein Source Wheat germ Species Human

Human EXOSC8 full length protein - ab180278 from Abcam Category Protein Source E. coli Species Human

Human EXOSC8 protein fragment - ab161420 from Abcam Category Protein Source Wheat germ Species Human

EXOSC8 Antibody Blocking Peptide - LS-E7094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Exosome component 8 Recombinant Protein - H00011340-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Exosome component 8 Partial Recombinant Protein - H00011340-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EXOSC8-Antibody-C-term-Blocking-Peptide - BP2783b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC8-Antibody-N-term-Blocking-Peptide - BP2783a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC8 protein (His tag) - 80R-3762 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

EXOSC8 (1-276, His-tag) - AR51449PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

EXOSC8 (1-276, His-tag) - AR51449PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

EXOSC8 - H00011340-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC8 - H00011340-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EXOSC8 / Exosome component 8 - H00011340-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

EXOSC8, 1-276aa, Human, His tag, E.coli - 01-P2629 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

EXOSC8 fusion protein - Ag17516 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EXOSC8 fusion protein - Ag2605 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EXOSC8, His-tagged - EXOSC8-12600H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EXOSC8, His-tagged - EXOSC8-136H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component RRP43(EXOSC8) - CSB-YP853387HU CSB-EP853387HU CSB-BP853387HU CSB-MP853387HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC8, 1-276aa, Human, His tag, E.coli - ATGP2629 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

EXOSC8 - TP304768 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Exosome component 8 Recombinant Protein Antigen - NBP2-47466PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Exosome component 8 Recombinant Protein Antigen - NBP2-47465PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Exosome Component 8 Protein (Recombinant) - abx262850 from Abbexa Category Protein

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