EXOSC8
| Gene Symbol | EXOSC8 |
|---|---|
| Entrez Gene | 11340 |
| Alt Symbol | CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | exosome component 8 |
| Other Description | CBP-interacting protein 3|OIP-2|Opa interacting protein 2|exosome complex component RRP43|exosome complex exonuclease RRP43|opa-interacting protein 2|ribosomal RNA-processing protein 43 |
| Swissprots | Q5TBA5 Q96B26 O43480 |
| Accessions | EAX08579 EAX08580 EAX08581 Q96B26 AF025438 AAC39558 AF279901 AK096810 AK126602 AL050353 CAI46226 BC020773 AAH20773 BM697343 BU687776 DQ893134 ABM84060 DQ896414 ABM87413 XM_006719763 XP_006719826 XR_429212 XR_941480 NM_181503 NP_852480 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}. |
| Top Pathways | RNA degradation |
EXOSC8 CRISPR/Cas9 KO Plasmid (h) - sc-405322 from Santa Cruz Biotechnology
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EXOSC8 HDR Plasmid (h) - sc-405322-HDR from Santa Cruz Biotechnology
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EXOSC8 Double Nickase Plasmid (h) - sc-405322-NIC from Santa Cruz Biotechnology
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EXOSC8 Double Nickase Plasmid (h2) - sc-405322-NIC-2 from Santa Cruz Biotechnology
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EXOSC8 CRISPR Activation Plasmid (h) - sc-405322-ACT from Santa Cruz Biotechnology
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EXOSC8 CRISPR Activation Plasmid (h2) - sc-405322-ACT-2 from Santa Cruz Biotechnology
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EXOSC8 Lentiviral Activation Particles (h) - sc-405322-LAC from Santa Cruz Biotechnology
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EXOSC8 Lentiviral Activation Particles (h2) - sc-405322-LAC-2 from Santa Cruz Biotechnology
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EXOSC8 siRNA (h) - sc-105341 from Santa Cruz Biotechnology
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EXOSC8 shRNA Plasmid (h) - sc-105341-SH from Santa Cruz Biotechnology
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EXOSC8 shRNA (h) Lentiviral Particles - sc-105341-V from Santa Cruz Biotechnology
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Exosome component 8 RNAi - H00011340-R01 from Novus Biologicals
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MISSION® esiRNA - EHU014101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8053 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8053 from Sigma-Aldrich
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EXOSC8 siRNA (Human) - CRH7767 from Cohesion Biosciences
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EXOSC8 - MBS8230607 from MyBioSource
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shRNA set against Human EXOSC8 (NM_181503.2) - SHH288165 from Creative biogene
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EXOSC8 shRNA Plasmid (Human) - CHH7767 from Cohesion Biosciences
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EXOSC8 miRNA 3'UTR clone - MiUTR3H-08141 from Creative biogene
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