NUMA1

Gene Symbol NUMA1
Entrez Gene 4926
Alt Symbol NMP-22, NUMA
Species Human
Gene Type protein-coding
Description nuclear mitotic apparatus protein 1
Other Description SP-H antigen|centrophilin stabilizes mitotic spindle in mitotic cells|nuclear matrix protein-22|structural nuclear protein
Swissprots Q14981 Q14980 Q9BTE9 H0YH75
Accessions AAC33408 AAD16994 EAW74821 EAW74822 EAW74823 EAW74824 EAW74825 EAW74826 EAW74827 EAW74828 EAW74829 EAW74830 EAW74831 Q14980 AB208841 BAD92078 AB210007 BAE06089 AB621824 BAK64159 AK290509 BAF83198 AK307577 AK309041 BC004165 AAH04165 BC008345 AAH08345 BC013023 AAH13023 BC027493 AAH27493 BC032228 BC036808 BC043499 AAH43499 BC068539 BC103765 AAI03766 BG754891 BG771637 DQ586970 Z11583 CAA77669 Z11584 CAA77670 Z14227 Z14228 Z14229 XM_006718564 XP_006718627 XM_011545054 XP_011543356 XM_011545055 XP_011543357 XM_011545056 XP_011543358 XM_011545057 XP_011543359 XM_011545058 XP_011543360 XM_011545059 XP_011543361 XM_011545060 XP_011543362 XM_011545061 XP_011543363 XM_011545062 XP_011543364 XM_011545063 XP_011543365 XM_011545064 XP_011543366 XM_011545065 XP_011543367 XM_011545066 XP_011543368 NM_001286561 NP_001273490 NM_006185 NP_006176 NR_104476
Function Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions. {ECO:0000269|PubMed:19255246}.
Subcellular Location Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.

Phospho-NuMA (Ser395) Antibody - 3429 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from M059K cells, untreated or UV-treated, using Phospho-NuMA (Ser395) Antibody.

NuMA Antibody - 3888 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using NuMA Antibody.

NuMA (D49H4) Rabbit mAb - 8967 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D49H4
Western blot analysis of extracts from various cell lines using NuMA (D49H4) Rabbit mAb.

NuMA (F-11) - sc-365532 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NuMA (F-11): sc-365532. Western blot analysis of NuMA expression in MOLT-4 nuclear extract.

NuMA (H-300) - sc-48773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NuMA (H-300): sc-48773. Immunofluorescence staining of normal mouse kidney frozen section showing nuclear staining.

NuMA (C-20) - sc-18557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NuMA (C-20): sc-18557. Western blot analysis of NuMA expression in CCRF-CEM (A) and Jurkat (B) nuclear extracts.

NuMA (N-20) - sc-18555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NuMA (A73-B/D12) - sc-56325 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
NuMA (A73-B/D12): sc-56325. Western blot analysis of NuMA expression in A549 (A), HeLa (B), MOLT-4 (C), A-673 (D), MCF7 (E) and CCRF-CEM (F) nuclear extracts.

NuMA (SPM300) - sc-56449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
NuMA (SPM300): sc-56449. Western blot analysis of NuMA expression in A549 (A), HeLa (B), MOLT-4 (C), A-673 (D), MCF7 (E) and CCRF-CEM (F) nuclear extracts.

Anti-NuMA antibody - ab97585 from Abcam

Prices $390.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-NuMA antibody (ab97585) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-NuMA antibody - ab86129 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NuMA antibody (ab86129) at 1 µg/ml + MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NuMA antibody - ab84680 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84680 staining NuMA in Marmoset (common) testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with Buoin's fixative, permeabilized in Triton X-100 (1/100 in PBS) and blocked with 25% serum for 30 minutes; antigen retrieval was by heat mediation in a citrate buffer, pH 6.0. Samples were incubated with primary antibody (1/100 in PBS + 0.5% BSA) for 17 hours at 4°C. A Biotin-conjugated Chicken anti-rabbit IgG polyclonal (1/100) was used as the secondary antibody.See Abreview

Anti-NuMA antibody - ab90521 from Abcam

Prices $359.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab90521, at a dilution of 1/100, staining NuMA in the nucleus of formalin fixed, paraffin embedded Human fetal spleen tissue by Immunohistochemistry.

Anti-NuMA antibody - ab55767 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NuMA antibody - ab36999 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab36999 at 1/1000 dilution, staining human HeLa cells fixed with 3.5% formaldehyde, by immunofluorescence, showing the typical pattern for NuMa in the cell nucleus during interphase and on spindles during mitosis.

Anti-NuMA antibody [A73-B/D12] - ab5675 from Abcam

Prices $373.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone A73-B/D12

Anti-NuMA antibody [EP3976] - ab109262 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP3976
All lanes : Anti-NuMA antibody [EP3976] (ab109262) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HeLa cell lysateLane 3 : MCF7 cell lysateLane 4 : Raji cell lysateLane 5 : SW480 cell lysateLane 6 : CACO2 cell lysateLane 7 : MOLT4 cell lysateLysates/proteins at 10 µg per lane.

Anti-NuMA antibody [GT3611] - ab184608 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT3611
All lanes : Anti-NuMA antibody [GT3611] (ab184608) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-NuMA antibody - C-terminal - ab199936 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-NuMA antibody - C-terminal (ab199936) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : Jurkat total cell extract

Anti-NUMA1 / NUMA Antibody (aa1-1193) - LS-C131120 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-NUMA1 / NUMA Antibody (C-Terminus) - LS-C136994 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-NUMA1 / NUMA Antibody (clone B497) - LS-C171016 from LifeSpan Bioscience

Prices $235.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone B497

Anti-NUMA1 / NUMA Antibody (clone A73-B/D12) - LS-C202423 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone A73-B/D12

Anti-NUMA1 / NUMA Antibody (clone C02142) - LS-C179470 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone C02142

Anti-NUMA1 / NUMA Antibody (aa1586-1635) - LS-C81567 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal lung lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.
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