| Gene Symbol |
NUMA1
|
| Entrez Gene |
4926
|
| Alt Symbol |
NMP-22, NUMA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear mitotic apparatus protein 1
|
| Other Description |
SP-H antigen|centrophilin stabilizes mitotic spindle in mitotic cells|nuclear matrix protein-22|structural nuclear protein
|
| Swissprots |
Q14981 Q14980 Q9BTE9 H0YH75
|
| Accessions |
AAC33408 AAD16994 EAW74821 EAW74822 EAW74823 EAW74824 EAW74825 EAW74826 EAW74827 EAW74828 EAW74829 EAW74830 EAW74831 Q14980 AB208841 BAD92078 AB210007 BAE06089 AB621824 BAK64159 AK290509 BAF83198 AK307577 AK309041 BC004165 AAH04165 BC008345 AAH08345 BC013023 AAH13023 BC027493 AAH27493 BC032228 BC036808 BC043499 AAH43499 BC068539 BC103765 AAI03766 BG754891 BG771637 DQ586970 Z11583 CAA77669 Z11584 CAA77670 Z14227 Z14228 Z14229 XM_006718564 XP_006718627 XM_011545054 XP_011543356 XM_011545055 XP_011543357 XM_011545056 XP_011543358 XM_011545057 XP_011543359 XM_011545058 XP_011543360 XM_011545059 XP_011543361 XM_011545060 XP_011543362 XM_011545061 XP_011543363 XM_011545062 XP_011543364 XM_011545063 XP_011543365 XM_011545064 XP_011543366 XM_011545065 XP_011543367 XM_011545066 XP_011543368 NM_001286561 NP_001273490 NM_006185 NP_006176 NR_104476
|
| Function |
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions. {ECO:0000269|PubMed:19255246}.
|
| Subcellular Location |
Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.
|