SLC4A1

Gene Symbol	SLC4A1
Entrez Gene	6521
Alt Symbol	AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR
Species	Human
Gene Type	protein-coding
Description	solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
Other Description	Diego blood group|Froese blood group|Swann blood group|Waldner blood group|Wright blood group|anion exchange protein 1|anion exchanger 1|anion exchanger-1|band 3 anion transport protein|erythrocyte membrane protein band 3|erythroid anion exchange protein|solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)|solute carrier family 4, anion exchanger, number 1
Swissprots	G4V2I6 Q4KKW9 Q9UDJ1 Q9UCY7 Q1ZZ45 P02730 Q4VB84 P78487
Accessions	AAA51670 AAA51671 AAY57324 ADN22950 ADN22951 ADN22952 ADN22953 ADN22954 ADN22955 EAW51614 P02730 AB526447 BAJ22989 AF113686 AM919470 CAP46016 BC096106 AAH96106 BC096107 AAH96107 BC099628 AAH99628 BC099629 AAH99629 BC101570 AAI01571 BC101574 AAI01575 DQ419529 ABD74692 GQ981383 ADN39420 GQ981384 ADN39421 GQ981385 ADN39422 GQ981386 ADN39423 GQ981387 ADN39424 M27819 AAA35514 S68680 AAC60608 X12609 CAA31128 XM_005257593 XP_005257650 XM_011525129 XP_011523431 XM_011525130 XP_011523432 XM_011525131 XP_011523433 NM_000342 NP_000333
Function	Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.
Tissue Specificity	Detected in erythrocytes (at protein level). Erythrocytes. {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:23219802}.
Top Pathways	Collecting duct acid secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Blood Group Wrb (BRIC14) - sc-59476 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

band 3 (A-6) - sc-133190 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

band 3 (H-105) - sc-20657 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

band 3 (Q1/156) - sc-53176 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

band 3 (C-17) - sc-20559 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

band 3 (BIII 136) - sc-58695 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

band 3 (N-20) - sc-20557 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

band 3 (L-22) - sc-130970 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Rabbit Clonality Polyclonal

Anti-Band 3 (phospho Y21) antibody [EPR1424] - ab125070 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1424

Anti-Band 3 (phospho Y359) antibody [EPR1427Y] - ab77236 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1427Y

Anti-Band 3 antibody - ab104998 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Band 3 antibody - ab78067 from Abcam Prices $378.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Band 3 antibody - ab172129 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Band 3 antibody [BIII 136] - ab11012 from Abcam Prices $373.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone BIII 136

Anti-Band 3 antibody [EPR1425(2)] - ab175214 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1425(2)

Anti-Band 3 antibody [EPR1426] - ab108414 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1426

Anti-Band 3 antibody - Aminoterminal end - ab55830 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC4A1 / Band 3 / AE1 Antibody (N-Terminus) - LS-C11863 from LifeSpan Bioscience Prices $365.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-SLC4A1 / Band 3 / AE1 Antibody (N-Terminus) - LS-C11862 from LifeSpan Bioscience Prices $530.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SLC4A1 / Band 3 / AE1 Antibody (N-Terminus) - LS-C11864 from LifeSpan Bioscience Prices $560.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC4A1 / Band 3 / AE1 Antibody - LS-C11866 from LifeSpan Bioscience Prices $385.00 Sizes 50 µl Host Mouse Clonality Monoclonal

Anti-SLC4A1 / Band 3 / AE1 Antibody (N-Terminus) - LS-C74633 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SLC4A1 / Band 3 / AE1 Antibody (phospho-Tyr359, clone EPR2668Y) - LS-C105438 from LifeSpan Bioscience Prices $450.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2668Y

Anti-SLC4A1 / Band 3 / AE1 Antibody (phospho-Tyr21, clone EPR1424) - LS-C138333 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1424

Anti-SLC4A1 / Band 3 / AE1 Antibody (aa35-290) - LS-C294028 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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