Gene Symbol | AP2S1 |
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Entrez Gene | 1175 |
Alt Symbol | AP17, CLAPS2, FBH3, FBHOk, HHC3 |
Species | Human |
Gene Type | protein-coding |
Description | adaptor-related protein complex 2, sigma 1 subunit |
Other Description | AP-2 complex subunit sigma|HA2 17 kDa subunit|adaptor protein complex AP-2 subunit sigma|clathrin assembly protein 2 sigma small chain|clathrin coat assembly protein AP17|clathrin coat-associated protein AP17|clathrin-associated/assembly/adaptor protein, small 2 (17kD)|plasma membrane adaptor AP-2 17 kDa protein|sigma2-adaptin |
Swissprots | P53680 O75977 B2R4Z4 Q6PK67 |
Accessions | EAW57448 EAW57449 P53680 AI139089 AJ010148 CAA09018 AJ010149 CAA09019 AJ713543 AK312003 BAG34941 BC006337 AAH06337 BF970609 BG282225 BI561502 BQ221562 BQ684675 BU564736 CA454481 CB108423 DB472500 H46780 JF432568 ADZ15785 X97074 CAA65782 XM_011526423 XP_011524725 XM_011526424 XP_011524726 NM_001301076 NP_001288005 NM_001301078 NP_001288007 NM_001301081 NP_001288010 NM_004069 NP_004060 NM_021575 NP_067586 |
Function | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p |
Subcellular Location | Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}. |
Top Pathways | Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle |
AP-2σ1 (5-RY21) - sc-134261 from Santa Cruz Biotechnology
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Anti-AP2S1 antibody - ab54661 from Abcam
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Anti-AP2S1 antibody [EPR2696] - ab92380 from Abcam
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Anti-AP2S1 antibody [EPR2697(2)] - ab128950 from Abcam
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Anti-AP2S1 Antibody (Biotin) - LS-C211720 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64, AP) - LS-C251461 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64, APC) - LS-C251462 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (Internal, clone EPR2696) - LS-C105595 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64, FITC) - LS-C251463 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64, Biotin) - LS-C251464 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64, Azide-free, HRP) - LS-C251465 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64, PE) - LS-C251466 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa35-64) - LS-C319512 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (aa36-64) - LS-C159081 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (Internal, clone EPR2697(2)) - LS-C152435 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (clone 3E4) - LS-C196929 from LifeSpan Bioscience
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Anti-AP2S1 Antibody - LS-C211718 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (HRP) - LS-C211717 from LifeSpan Bioscience
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Anti-AP2S1 Antibody (FITC) - LS-C211719 from LifeSpan Bioscience
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AP2S1 Antibody (3E4.) - H00001175-M01 from Novus Biologicals
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AP2S1 Antibody - H00001175-A01 from Novus Biologicals
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Anti-AP2S1 (11-25) antibody produced in rabbit - A2236 from Sigma-Aldrich
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Anti-AP2S1 antibody produced in rabbit - SAB4300811 from Sigma-Aldrich
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AP2S1-Antibody-Center - AP17428c from Abgent, a WuXi AppTec company
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AP2S1-Antibody-monoclonal-M01 - AT1153a from Abgent, a WuXi AppTec company
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