AP2S1

Gene Symbol AP2S1
Entrez Gene 1175
Alt Symbol AP17, CLAPS2, FBH3, FBHOk, HHC3
Species Human
Gene Type protein-coding
Description adaptor-related protein complex 2, sigma 1 subunit
Other Description AP-2 complex subunit sigma|HA2 17 kDa subunit|adaptor protein complex AP-2 subunit sigma|clathrin assembly protein 2 sigma small chain|clathrin coat assembly protein AP17|clathrin coat-associated protein AP17|clathrin-associated/assembly/adaptor protein, small 2 (17kD)|plasma membrane adaptor AP-2 17 kDa protein|sigma2-adaptin
Swissprots P53680 O75977 B2R4Z4 Q6PK67
Accessions EAW57448 EAW57449 P53680 AI139089 AJ010148 CAA09018 AJ010149 CAA09019 AJ713543 AK312003 BAG34941 BC006337 AAH06337 BF970609 BG282225 BI561502 BQ221562 BQ684675 BU564736 CA454481 CB108423 DB472500 H46780 JF432568 ADZ15785 X97074 CAA65782 XM_011526423 XP_011524725 XM_011526424 XP_011524726 NM_001301076 NP_001288005 NM_001301078 NP_001288007 NM_001301081 NP_001288010 NM_004069 NP_004060 NM_021575 NP_067586
Function Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p
Subcellular Location Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
Top Pathways Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle

AP-2σ1 (5-RY21) - sc-134261 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
AP-2σ1 (5-RY21): sc-134261. Western blot analysis of AP-2σ1 expression in human AP-21 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-AP2S1 antibody - ab54661 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54661 AP2S1 antibody at 1ug/ml.

Anti-AP2S1 antibody [EPR2696] - ab92380 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2696
All lanes : Anti-AP2S1 antibody [EPR2696] (ab92380) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-AP2S1 antibody [EPR2697(2)] - ab128950 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2697(2)
All lanes : Anti-AP2S1 antibody [EPR2697(2)] (ab128950) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : SH-SY5Y lysateLane 3 : 293T lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-AP2S1 Antibody (Biotin) - LS-C211720 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa36-64, AP) - LS-C251461 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa36-64, APC) - LS-C251462 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (Internal, clone EPR2696) - LS-C105595 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2696
Western blot analysis on (A) fetal brain and (B) HeLa cell lysates using anti-AP2S1 antibody (LS-C105595).

Anti-AP2S1 Antibody (aa36-64, FITC) - LS-C251463 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa36-64, Biotin) - LS-C251464 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa36-64, Azide-free, HRP) - LS-C251465 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa36-64, PE) - LS-C251466 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa35-64) - LS-C319512 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (aa36-64) - LS-C159081 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AP2S1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The AP2S1 antibody detected the AP2S1 protein (arrow).

Anti-AP2S1 Antibody (Internal, clone EPR2697(2)) - LS-C152435 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2697(2)
IHC of paraffin-embedded human colon carcinoma tissue using anti-AP2S1 antibody.

Anti-AP2S1 Antibody (clone 3E4) - LS-C196929 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E4
Western Blot analysis of AP2S1 expression in transfected 293T cell line by AP2S1 monoclonal antibody (M01), clone 3E4.Lane 1: AP2S1 transfected lysate(17 KDa).Lane 2: Non-transfected lysate.

Anti-AP2S1 Antibody - LS-C211718 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (HRP) - LS-C211717 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AP2S1 Antibody (FITC) - LS-C211719 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

AP2S1 Antibody (3E4.) - H00001175-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E4.

AP2S1 Antibody - H00001175-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-AP2S1 (11-25) antibody produced in rabbit - A2236 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human AP2S1 was separated on SDS-PAGE, blotted with Anti-AP2S1 (11-25) (<B>Cat. No. A2236</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250

Anti-AP2S1 antibody produced in rabbit - SAB4300811 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AP2S1-Antibody-Center - AP17428c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
AP2S1 Antibody (Center) (Cat. #AP17428c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the AP2S1 antibody detected the AP2S1 protein (arrow).

AP2S1-Antibody-monoclonal-M01 - AT1153a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E5
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (41.36 KDa) .
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