AP2S1

Gene Symbol	AP2S1
Entrez Gene	1175
Alt Symbol	AP17, CLAPS2, FBH3, FBHOk, HHC3
Species	Human
Gene Type	protein-coding
Description	adaptor-related protein complex 2, sigma 1 subunit
Other Description	AP-2 complex subunit sigma|HA2 17 kDa subunit|adaptor protein complex AP-2 subunit sigma|clathrin assembly protein 2 sigma small chain|clathrin coat assembly protein AP17|clathrin coat-associated protein AP17|clathrin-associated/assembly/adaptor protein, small 2 (17kD)|plasma membrane adaptor AP-2 17 kDa protein|sigma2-adaptin
Swissprots	P53680 O75977 B2R4Z4 Q6PK67
Accessions	EAW57448 EAW57449 P53680 AI139089 AJ010148 CAA09018 AJ010149 CAA09019 AJ713543 AK312003 BAG34941 BC006337 AAH06337 BF970609 BG282225 BI561502 BQ221562 BQ684675 BU564736 CA454481 CB108423 DB472500 H46780 JF432568 ADZ15785 X97074 CAA65782 XM_011526423 XP_011524725 XM_011526424 XP_011524726 NM_001301076 NP_001288005 NM_001301078 NP_001288007 NM_001301081 NP_001288010 NM_004069 NP_004060 NM_021575 NP_067586
Function	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p
Subcellular Location	Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
Top Pathways	Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AP2S1 protein (His-DHFR tag) - ab127625 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

AP2S1 Antibody Blocking Peptide - LS-E5025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AP2S1 Protein - H00001175-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AP2S1-Antibody-Center-Blocking-Peptide - BP17428c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human AP-2 complex subunit sigma protein (OPCA00465) - OPCA00465 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human AP2S1 protein - orb245140 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

AP2 complex subunit sigma-1 - H00001175-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AP2 complex subunit sigma-1 - H00001175-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AP2S1 fusion protein - ag8095 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AP2S1 fusion protein - Ag8169 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human AP2S1, His-tagged - AP2S1-3537H from Creative Biomart Category Protein Source E. Coli or Yeast Species Human

Recombinant human AP-2 complex subunit sigma protein - CSB-EP026044h CSB-BP026044h CSB-MP026044h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human AP-2 complex subunit sigma protein - CSB-RP026044h from Cusabio Category Protein Source E.coli Species Human

Recombinant Human AP-2 complex subunit sigma(AP2S1) - CSB-YP001873HU CSB-EP001873HU CSB-BP001873HU CSB-MP001873HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

AP-2 complex subunit sigma protein - RPC140170 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

AP2 complex subunit sigma-1 / AP2S1 (transcript variant AP17) - TP302919 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

AP-2 complex subunit sigma (AP2S1) , Recombinant Protein - MBS954417 from MyBioSource Category Protein Prices $1,290.00, $1,290.00, $1,745.00, $1,745.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

AP-2 complex subunit sigma (AP2S1) , Recombinant Protein - MBS1403095 from MyBioSource Category Protein Prices $1,290.00, $1,290.00, $1,745.00, $1,745.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

AP-2 complex subunit sigma (aps-2) , Recombinant Protein - MBS1296671 from MyBioSource Category Protein Prices $1,290.00, $1,290.00, $1,745.00, $1,745.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Neurospora crassa

AP-2 complex subunit sigma (APS2) , Recombinant Protein - MBS1454743 from MyBioSource Category Protein Prices $1,290.00, $1,290.00, $1,745.00, $1,745.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Wheat

AP-2 complex subunit sigma protein, Recombinant Protein - MBS717158 from MyBioSource Category Protein Prices $195.00, $465.00, $815.00, $1,290.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli

AP-2 complex subunit sigma(aps2) , Recombinant Protein - MBS1399827 from MyBioSource Category Protein Prices $1,300.00, $1,300.00, $1,755.00, $1,755.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Emericella

AP-2 complex subunit sigma(aps2) , Recombinant Protein - MBS1421659 from MyBioSource Category Protein Prices $1,300.00, $1,300.00, $1,755.00, $1,755.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Neosartorya

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