MICAL2

Gene Symbol MICAL2
Entrez Gene 9645
Alt Symbol MICAL-2, MICAL2PV1, MICAL2PV2
Species Human
Gene Type protein-coding
Description microtubule associated monooxygenase, calponin and LIM domain containing 2
Other Description flavoprotein oxidoreductase MICAL2|microtubule associated monoxygenase, calponin and LIM domain containing 2|molecule interacting with CasL protein 2|protein-methionine sulfoxide oxidase MICAL2
Swissprots Q7Z3A8 O94851 G3XAC8 B7Z849 Q5KTR3 B4DGZ0 Q5KTR4 D3DQW5
Accessions CAG27589 CAG27590 CBB98512 CBB98513 CCQ43448 EAW68528 EAW68529 EAW68530 EAW68531 O94851 AB018293 BAA34470 AB110785 BAD83656 AB110786 BAD83657 AF052170 AK025186 AK026116 AK090550 AK122821 AK125552 AK125785 AK127301 AK294845 BAG57951 AK302580 BAG63835 AK302893 BAH13835 AL046982 BC015755 BC017104 BC044577 AAH44577 BC048206 BC063589 BG939697 BK000462 DAA01341 BX538021 CAD97967 BX641163 CAE46072 DA246062 XM_005253249 XP_005253306 XM_011520490 XP_011518792 XM_011520491 XP_011518793 NM_001282663 NP_001269592 NM_001282664 NP_001269593 NM_001282665 NP_001269594 NM_001282666 NP_001269595 NM_001282667 NP_001269596 NM_001282668 NP_001269597 NM_014632 NP_055447
Function Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine- sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. {ECO:0000269|PubMed:23927065, ECO:0000269|PubMed:24440334}.
Subcellular Location Nucleus {ECO:0000269|PubMed:24440334}.

MICAL2 (K-14) - sc-135497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MICAL2 (K-14): sc-135497. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoskeletal localization.

MICAL2 (L-12) - sc-135498 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MICAL2 antibody - ab103044 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-MICAL2 antibody (ab103044) at 1/50 dilution + WiDr cell line lysates at 35 µg

Anti-MICAL2 Antibody (aa630-679) - LS-C187373 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. MICAL2 antibody dilution 1.0 ug/ml.

Anti-MICAL2 Antibody (aa46-95) - LS-C187374 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat. MICAL2 antibody dilution 1.0 ug/ml.

Anti-MICAL2 Antibody (aa55-83) - LS-C164187 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of MICAL2 Antibody in WiDr cell line lysates (35 ug/lane). MICAL2 (arrow) was detected using the purified antibody.

MICAL2 Antibody - NBP1-81483 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MICAL2 Antibody [NBP1-81483] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY415152)

ANTI-MICAL2 (N-TERM) antibody produced in rabbit - SAB1304816 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MICAL2 (N-term): <B>Cat. No. SAB1304816</B>: Western blot analysis of MICAL2 Antibody (N-term) in WiDr cell line lysates (35 μg/lane).

Anti-MICAL2 antibody produced in rabbit - HPA030437 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MICAL2: <B>Cat. No. HPA030437</B>: Immunohistochemical staining of human liver shows moderate cytoplasmic and membranous positivity in hepatocytes.

MICAL2 Antibody - C-terminal region (ARP67657_P050) - ARP67657_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MICAL2 Antibody - N-terminal region (ARP67658_P050) - ARP67658_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MICAL2-Antibody-N-term - AP9597a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of MICAL2 Antibody (N-term) (Cat. #AP9597a) in WiDr cell line lysates (35ug/lane). MICAL2 (arrow) was detected using the purified Pab.

MICAL2 Antibody - N-terminal region (OAAB06193) - OAAB06193 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

MICAL2 antibody - GTX53677 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-MICAL2 antibody used in Western blot. GTX53677

MICAL2 antibody - 70R-18511 from Fitzgerald

Host Rabbit
Clonality Polyclonal

MICAL2 Antibody - abx034434 from Abbexa

Host Rabbit
Clonality Polyclonal

MICAL2 antibody - 13965-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded H-brain using 13965-1-AP(MICAL2 Antibody) at Dilution 1:100 (under 10x lens)

MICAL2 (N-term) antibody - AP52693PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of MICAL2 (arrow) in WiDr cell line lysates (35ug/lane) using MICAL2 antibody Cat.-No. AP52693PU-N.

Rabbit Anti-Human MICAL2 (N-term) - 102-18323 from RayBiotech

Host Rabbit

MICAL2 antibody (N-term) - STJ52033 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB18640

MICAL2 antibody - 13965-1-AP from Proteintech Group

Prices $279.00
Sizes con: 26 μg/150μl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human brain using 13965-1-AP(MICAL2 antibody) at dilution of 1:100 (under 10x lens)

Anti-MICAL2 (aa 630-679) polyclonal antibody - DPABH-12934 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

MICAL2 Polyclonal Antibody - PA5-26602 from Thermo Fisher Scientific

Prices $349.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis using a MICAL2 polyclonal antibody (Product # PA5-26602) in WiDr cell lysates (35ug per lane).

MICAL2, Polyclonal Antibody - MBS6001984 from MyBioSource

Prices $550.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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