| Gene Symbol |
MICAL2
|
| Entrez Gene |
9645
|
| Alt Symbol |
MICAL-2, MICAL2PV1, MICAL2PV2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule associated monooxygenase, calponin and LIM domain containing 2
|
| Other Description |
flavoprotein oxidoreductase MICAL2|microtubule associated monoxygenase, calponin and LIM domain containing 2|molecule interacting with CasL protein 2|protein-methionine sulfoxide oxidase MICAL2
|
| Swissprots |
Q7Z3A8 O94851 G3XAC8 B7Z849 Q5KTR3 B4DGZ0 Q5KTR4 D3DQW5
|
| Accessions |
CAG27589 CAG27590 CBB98512 CBB98513 CCQ43448 EAW68528 EAW68529 EAW68530 EAW68531 O94851 AB018293 BAA34470 AB110785 BAD83656 AB110786 BAD83657 AF052170 AK025186 AK026116 AK090550 AK122821 AK125552 AK125785 AK127301 AK294845 BAG57951 AK302580 BAG63835 AK302893 BAH13835 AL046982 BC015755 BC017104 BC044577 AAH44577 BC048206 BC063589 BG939697 BK000462 DAA01341 BX538021 CAD97967 BX641163 CAE46072 DA246062 XM_005253249 XP_005253306 XM_011520490 XP_011518792 XM_011520491 XP_011518793 NM_001282663 NP_001269592 NM_001282664 NP_001269593 NM_001282665 NP_001269594 NM_001282666 NP_001269595 NM_001282667 NP_001269596 NM_001282668 NP_001269597 NM_014632 NP_055447
|
| Function |
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine- sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. {ECO:0000269|PubMed:23927065, ECO:0000269|PubMed:24440334}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24440334}.
|