| Gene Symbol |
PRKAG1
|
| Entrez Gene |
5571
|
| Alt Symbol |
AMPKG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
|
| Other Description |
5'-AMP-activated protein kinase subunit gamma-1|5'-AMP-activated protein kinase, gamma-1 subunit|AMPK gamma-1 chain|AMPK gamma1
|
| Swissprots |
P54619 Q8N7V9 B4DDT7
|
| Accessions |
EAW58032 EAW58033 P54619 AK097606 BAC05117 AK293332 BAG56848 AK303276 BAG64356 AK307994 AK310250 BC000358 AAH00358 BG772337 BG772412 BI757340 BM667691 BM972308 BT007345 AAP36009 CB124830 DB020277 XM_005269019 XP_005269076 XM_005269020 XP_005269077 XM_006719499 XP_006719562 XM_006719500 XP_006719563 XM_011538562 XP_011536864 NM_001206709 NP_001193638 NM_001206710 NP_001193639 NM_002733 NP_002724 NM_212461
|
| Function |
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm
|
![Western Blot: AMPK gamma 1 Overexpression Lysate (Adult Normal) [NBL1-14760] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AMPK gamma 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1175_AMPK%2520gamma%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14760-img0002.jpg)
![Western Blot: AMPK gamma 1 Overexpression Lysate (Adult Normal) [NBL1-14759] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AMPK gamma 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5726_AMPK%2520gamma%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14759-img0002.jpg)