PRKAG1
| Gene Symbol | PRKAG1 |
|---|---|
| Entrez Gene | 5571 |
| Alt Symbol | AMPKG |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, AMP-activated, gamma 1 non-catalytic subunit |
| Other Description | 5'-AMP-activated protein kinase subunit gamma-1|5'-AMP-activated protein kinase, gamma-1 subunit|AMPK gamma-1 chain|AMPK gamma1 |
| Swissprots | P54619 Q8N7V9 B4DDT7 |
| Accessions | EAW58032 EAW58033 P54619 AK097606 BAC05117 AK293332 BAG56848 AK303276 BAG64356 AK307994 AK310250 BC000358 AAH00358 BG772337 BG772412 BI757340 BM667691 BM972308 BT007345 AAP36009 CB124830 DB020277 XM_005269019 XP_005269076 XM_005269020 XP_005269077 XM_006719499 XP_006719562 XM_006719500 XP_006719563 XM_011538562 XP_011536864 NM_001206709 NP_001193638 NM_001206710 NP_001193639 NM_002733 NP_002724 NM_212461 |
| Function | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread |
| Top Pathways | Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm |
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