TYR

Gene Symbol TYR
Entrez Gene 7299
Alt Symbol ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3
Species Human
Gene Type protein-coding
Description tyrosinase
Other Description LB24-AB|SK29-AB|monophenol monooxygenase|oculocutaneous albinism IA|tumor rejection antigen AB
Swissprots Q15675 Q9BYY0 Q15680 Q15676 P14679 Q9BZX1 Q8TAK4
Accessions AAA61242 AAD13985 AAG38762 AAK00805 AGV39051 AGV39052 AGV39053 AGV39055 AGV39056 AGV39057 AGV39058 AGV39059 AGV39060 AGV39061 AGV39062 AGV39063 AGV39064 AGV39065 AGV39066 AGV39067 AGV39068 AGV39069 AGV39070 AGV39071 AGV39072 AGV39073 AGV39074 AGV39075 AGV39076 AGV39077 AGV39078 AGV39079 AGV39080 AGV39081 AGV39085 AGV39088 AGV39093 AGV39094 AGV39097 AGV39098 AGV39099 AGV39100 AGV39101 AGV39103 AGV39105 AGV39106 AGV39107 AGV39108 AGV39109 AGV39110 AGV39111 AGV39112 AGV39113 AGV39114 AGV39115 AGV39116 AGV39117 AGV39118 AGV39119 AGV39120 AGV39121 AGV39124 AGV39125 AGV39126 AGV39127 AGV39128 AGV39129 AGV39130 AGV39131 AGV39133 AGV39134 AGV39135 AGV39136 AGV39137 AGV39138 AGV39139 AGV39140 AGV39141 AGV39142 AGV39143 AGV39144 AGV39145 AGV39146 AGV39147 AGV39148 AGV39149 AGV39150 AGV39151 AGV39152 AGV39153 AGV39154 AGV39155 AGV39156 AGV39157 AGV39158 AGV39159 AGV39160 AGV39161 AGV39163 AGV39169 AGV39174 AGV39177 AGV39178 AGV39179 AGV39180 AGV39181 AGV39182 AGV39183 AGV39184 AGV39185 AGV39186 AGV39187 AGV39189 AGV39190 AGV39191 AGV39193 AGV39195 AGV39196 AGV39197 AGV39198 AGV39199 AGV39200 AGV39201 AGV39202 AGV39203 AGV39204 AGV39205 AGV39206 AGV39207 AGV39208 AGV39209 AGV39210 AHZ44440 CAA34205 EAW59356 EAW59357 P14679 AB775899 BAM75356 AB775900 BAM75357 AB775901 BAM75358 BC027179 AAH27179 BU736025 J03581 AAA61241 M27160 AAB37227 M74314 AAA61244 S66645 AAD13984 U01873 AAB60319 Y00819 CAA68756 XM_011542970 XP_011541272 NM_000372 NP_000363
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Subcellular Location Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
Top Pathways Melanogenesis, Tyrosine metabolism, Riboflavin metabolism

Tyrosinase (T311) Mouse mAb (IHC Specific) - 9319 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (50 sections)
Host Mouse
Clonality Monoclonal
Clone T311
Immunohistochemical analysis of human colon tissue using Tyrosinase (T311) Mouse mAb (IHC Specific). Note the lack of staining in the tyrosinase negative tissue.

Tyrosinase (M-19) - sc-7834 from Santa Cruz Biotechnology

Host Goat
Clonality Polyclonal
Tyrosinase (M-19): sc-7834. Immunofluorescence staining of methanol-fixed B16-FO cells showing cytoplasmic staining.

Tyrosinase (C-19) - sc-7833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tyrosinase (C-19) PE: sc-7833 PE. Intracellular FCM analysis of fixed and permeabilized B16-FO cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

Tyrosinase (H-109) - sc-15341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tyrosinase (H-109): sc-15341. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic localization.

Tyrosinase (T311) - sc-20035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyrosinase (T311): sc-20035. Western blot analysis of Tyrosinase expression in A-375 (A) and SK-MEL 24 (B) whole cell lysates.

Tyrosinase (SPM360) - sc-56494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Tyrosinase (0.N.596) - sc-73243 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyrosinase (0.N.596): sc-73243. Western blot analysis of Tyrosinase expression in non-transfected 293T: sc-117752 (A), human Tyrosinase transfected 293T: sc-113710 (B) and A-375 (C) whole cell lysates.

Tyrosinase (6A207) - sc-73244 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyrosinase (6A207): sc-73244. Western blot analysis of Tyrosinase expression in non-transfected 293T: sc-117752 (A), human Tyrosinase transfected 293T: sc-113710 (B) and A-375 (C) whole cell lysates.

Anti-Tyrosinase antibody - ab196874 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Tyrosinase antibody (ab196874) at 1/500 dilution + HepG2 cell lysate

Anti-Tyrosinase antibody - ab58284 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab58284 stained MALME-3M cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab58284 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Dylight® 488 goat anti- mouse (ab96879) IgG (H+L) preadsorbed, used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-Tyrosinase antibody - ab58450 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab58450 stained Malme-3M cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab58450 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Tyrosinase antibody - ab53338 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Tyrosinase antibody [1F3] - ab157253 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F3
All lanes : Anti-Tyrosinase antibody [1F3] (ab157253) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Tyrosinase cDNALysates/proteins at 5 µg per lane.

Anti-Tyrosinase antibody [EPR10141] - ab170905 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10141
Immunohistochemical analysis of paraffin-embedded Human melanoma tissue, labeling Tyrosinase using ab170905 at a 1/100 dilution.

Anti-Tyrosinase antibody [T311] - ab738 from Abcam

Prices $392.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone T311
Anti-Tyrosinase antibody [T311] (ab738) at 1/250 dilution + Human A375 whole cell lysate at 10000 cellsSecondaryHRP-conjugated Horse anti-mouse IgG polyclonal at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Observed band size : 65 kDa (why is the actual band size different from the predicted?)Exposure time : 10 minutesThis image is courtesy of an anonymous Abreview See Abreview

Anti-Tyrosinase antibody [T311], prediluted - ab59771 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone T311

Anti-Tyrosinase antibody - C-terminal - ab175997 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Tyrosinase antibody - C-terminal (ab175997) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-Phospho-Ser/Thr/Tyr Antibody (clone SPM101) IHC-plus™ - LS-B2784 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone SPM101
Anti-Phospho-Ser/Thr/Tyr antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2784 concentration 10 ug/ml.

Anti-Phospho-Ser/Thr/Tyr Antibody (clone SPM101) - LS-C182399 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone SPM101

Anti-Phospho-Ser/Thr/Tyr Antibody (clone SPM101) - LS-C33752 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone SPM101

Anti-Tyrosinase Antibody (aa492-522) - LS-C160356 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Tyrosinase Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skin tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-Tyrosinase Antibody - LS-C331387 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach cancer using TYR antibody at dilution of 1:100 (200x lens).

Anti-Tyrosinase Antibody (aa5-456) - LS-C18401 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-Tyrosinase Antibody - LS-C18406 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Tyrosinase Antibody - LS-C18404 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Search more