TYR

Gene Symbol	TYR
Entrez Gene	7299
Alt Symbol	ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3
Species	Human
Gene Type	protein-coding
Description	tyrosinase
Other Description	LB24-AB|SK29-AB|monophenol monooxygenase|oculocutaneous albinism IA|tumor rejection antigen AB
Swissprots	Q15675 Q9BYY0 Q15680 Q15676 P14679 Q9BZX1 Q8TAK4
Accessions	AAA61242 AAD13985 AAG38762 AAK00805 AGV39051 AGV39052 AGV39053 AGV39055 AGV39056 AGV39057 AGV39058 AGV39059 AGV39060 AGV39061 AGV39062 AGV39063 AGV39064 AGV39065 AGV39066 AGV39067 AGV39068 AGV39069 AGV39070 AGV39071 AGV39072 AGV39073 AGV39074 AGV39075 AGV39076 AGV39077 AGV39078 AGV39079 AGV39080 AGV39081 AGV39085 AGV39088 AGV39093 AGV39094 AGV39097 AGV39098 AGV39099 AGV39100 AGV39101 AGV39103 AGV39105 AGV39106 AGV39107 AGV39108 AGV39109 AGV39110 AGV39111 AGV39112 AGV39113 AGV39114 AGV39115 AGV39116 AGV39117 AGV39118 AGV39119 AGV39120 AGV39121 AGV39124 AGV39125 AGV39126 AGV39127 AGV39128 AGV39129 AGV39130 AGV39131 AGV39133 AGV39134 AGV39135 AGV39136 AGV39137 AGV39138 AGV39139 AGV39140 AGV39141 AGV39142 AGV39143 AGV39144 AGV39145 AGV39146 AGV39147 AGV39148 AGV39149 AGV39150 AGV39151 AGV39152 AGV39153 AGV39154 AGV39155 AGV39156 AGV39157 AGV39158 AGV39159 AGV39160 AGV39161 AGV39163 AGV39169 AGV39174 AGV39177 AGV39178 AGV39179 AGV39180 AGV39181 AGV39182 AGV39183 AGV39184 AGV39185 AGV39186 AGV39187 AGV39189 AGV39190 AGV39191 AGV39193 AGV39195 AGV39196 AGV39197 AGV39198 AGV39199 AGV39200 AGV39201 AGV39202 AGV39203 AGV39204 AGV39205 AGV39206 AGV39207 AGV39208 AGV39209 AGV39210 AHZ44440 CAA34205 EAW59356 EAW59357 P14679 AB775899 BAM75356 AB775900 BAM75357 AB775901 BAM75358 BC027179 AAH27179 BU736025 J03581 AAA61241 M27160 AAB37227 M74314 AAA61244 S66645 AAD13984 U01873 AAB60319 Y00819 CAA68756 XM_011542970 XP_011541272 NM_000372 NP_000363
Function	This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Subcellular Location	Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
Top Pathways	Melanogenesis, Tyrosine metabolism, Riboflavin metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tyrosinase CRISPR/Cas9 KO Plasmid (h) - sc-400255 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase HDR Plasmid (h) - sc-400255-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase Double Nickase Plasmid (h) - sc-400255-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase Double Nickase Plasmid (h2) - sc-400255-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase CRISPR Activation Plasmid (h) - sc-400255-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase CRISPR Activation Plasmid (h2) - sc-400255-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase Lentiviral Activation Particles (h) - sc-400255-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase Lentiviral Activation Particles (h2) - sc-400255-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyrosinase siRNA (h) - sc-36766 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tyrosinase shRNA Plasmid (h) - sc-36766-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tyrosinase shRNA (h) Lentiviral Particles - sc-36766-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tyrosinase RNAi - H00007299-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU117771 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU055031 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22322 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22322 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03433 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03433

TYR siRNA (Human) - CRH4993 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TYR - MBS828810 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TYR(NM_000372.4) - SHL108820 from Creative biogene Category siRNA Species Reactivities Human

Human TYR siRNA - orb265495 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TYR shRNA Plasmid (Human) - CHH4993 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TYR miRNA 3'UTR clone - MiUTR1H-10908 from Creative biogene Species Reactivities Human

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