PAXIP1

Gene Symbol	PAXIP1
Entrez Gene	22976
Alt Symbol	CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2
Species	Human
Gene Type	protein-coding
Description	PAX interacting (with transcription-activation domain) protein 1
Other Description	PAX transcription activation domain interacting protein 1 like|PAX-interacting protein 1|protein encoded by CAG trinucleotide repeats
Swissprots	Q7Z315 Q6ZWH9 O15404 Q6N099 Q6ZW49 Q86UN0 Q96HP2 Q8N4P9
Accessions	AAP21865 EAX04524 EAX04525 Q6ZW49 AK093584 AK123044 BAC85523 AK123600 BAC85657 AK126674 BAG54355 AK293744 BAG57167 AK307417 BC008328 AAH08328 BC033781 AAH33781 BQ222021 BX538201 CAD98066 BX640616 CAE45762 CR993144 U80735 AAB91434 XM_005249539 XP_005249596 XM_011515982 XP_011514284 XM_011515983 XP_011514285 XM_011515984 XP_011514286 NM_007349 NP_031375
Function	Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chroma
Subcellular Location	Nucleus matrix {ECO:0000250}. Note=Localizes to DNA damage foci upon ionizing radiation. {ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PTIP full length protein - ab153199 from Abcam Category Protein Source Wheat germ Species Human

Human PTIP peptide - ab13757 from Abcam Category Peptide Species Human

Human PTIP protein fragment - ab153200 from Abcam Category Protein Source Wheat germ Species Human

PAXIP1 / PTIP Antibody Blocking Peptide - LS-E18514 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PTIP Protein - H00022976-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PTIP Protein - H00022976-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PAXIP1 Blocking Peptide - 33R-5988 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PAXIP1 - H00022976-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PAXIP1 - H00022976-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAXIP1 - H00022976-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PAXIP1 fusion protein - Ag4567 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human PAX-interacting protein 1(PAXIP1) ,partial - CSB-YP761652HU CSB-EP761652HU CSB-BP761652HU CSB-MP761652HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PAX-interacting protein 1 (PAXIP1), partial, Recombinant Protein - MBS1353590 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PTIP Recombinant Protein Antigen - NBP2-33877PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PTIP Protein - NBP1-88233PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

PAXIP1-Blocking-Peptide-N-term - BP20825a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAXIP1 Peptide, Human - M34GP11349H from Creative Peptides Category Peptide Source Synthetic. Species Human

PAXIP1 fusion protein - Ag26485 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

PAXIP1 fusion protein - Ag27113 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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