PAXIP1

Gene Symbol PAXIP1
Entrez Gene 22976
Alt Symbol CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2
Species Human
Gene Type protein-coding
Description PAX interacting (with transcription-activation domain) protein 1
Other Description PAX transcription activation domain interacting protein 1 like|PAX-interacting protein 1|protein encoded by CAG trinucleotide repeats
Swissprots Q7Z315 Q6ZWH9 O15404 Q6N099 Q6ZW49 Q86UN0 Q96HP2 Q8N4P9
Accessions AAP21865 EAX04524 EAX04525 Q6ZW49 AK093584 AK123044 BAC85523 AK123600 BAC85657 AK126674 BAG54355 AK293744 BAG57167 AK307417 BC008328 AAH08328 BC033781 AAH33781 BQ222021 BX538201 CAD98066 BX640616 CAE45762 CR993144 U80735 AAB91434 XM_005249539 XP_005249596 XM_011515982 XP_011514284 XM_011515983 XP_011514285 XM_011515984 XP_011514286 NM_007349 NP_031375
Function Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chroma
Subcellular Location Nucleus matrix {ECO:0000250}. Note=Localizes to DNA damage foci upon ionizing radiation. {ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115}.

PTIP (C-20) - sc-79277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PTIP (H-167) - sc-367459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PTIP (H-167): sc-367459. Western blot analysis of PTIP expression in mouse brain tissue extract.

PTIP (T-20) - sc-79280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTIP (T-20): sc-79280. Western blot analysis of PTIP expression in SH-SY5Y nuclear extract.

Anti-PTIP antibody - ab2614 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab2614 staining PTIP in mouse embryonic fibroblasts by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with Triton X-100 in PBS and blocked with 20% serum for 1 hour at 22°C. Samples were incubated with primary antibody (1/300) for 18 hours at 4°C. An Cy3®-conjugated goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody.See Abreview

Anti-PTIP antibody - ab70434 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lanes 1, 4 & 7 : Anti-PTIP antibody (ab70434) at 0.25 µg/mlLanes 2, 5 & 8 : Anti-PTIP antibody (ab70434) at 0.1 µg/mlLanes 3, 6 & 9 : Anti-PTIP antibody (ab70434) at 0.025 µg/mlLane 1 : Whole cell lysate from 293T cells at 5 µgLane 2 : Whole cell lysate from 293T cells at 15 µgLane 3 : Whole cell lysate from 293T cells at 50 µgLane 4 : Whole cell lysate from 293T cells at 5 µgLane 5 : Whole cell lysate from 293T cells at 15 µgLane 6 : Whole cell lysate from 293T cells at 50 µgLane 7 : Whole cell lysate from 293T cells at 5 µgLane 8 : Whole cell lysate from 293T cells at 15 µgLane 9 : Whole cell lysate from 293T cells at 50 µgdeveloped using the ECL technique

Anti-PTIP antibody - ab168502 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PTIP antibody (ab168502) at 1 µg/mlLane 1 : PTIP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-PTIP antibody - ab121253 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTIP antibody (ab121253) at 1/250 dilutionLane 1 : Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 Lane 2 : RT-4 lysateLane 3 : U-251 MG lysateLane 4 : Human plasma lysateLane 5 : Liver lysateLane 6 : Tonsil lysate

Anti-PTIP antibody - ab56934 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56934 PTIP antibody at 1ug/ml.

Anti-PAXIP1 / PTIP Antibody (aa205-218) - LS-C17501 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAXIP1 / PTIP Antibody (aa1-50) - LS-C91657 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAXIP1 / PTIP Antibody (aa1-50) - LS-C287267 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAXIP1 / PTIP Antibody (aa248-297) - LS-C81652 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-PAXIP1 / PTIP Antibody (aa800-850) - LS-C287265 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PTIP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-PTIP antibody used for IP at 6 ug/mg lysate. PTIP was also immunoprecipitated by a previous lot of this antibody. For blotting immunoprecipitated PTIP, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-PAXIP1 / PTIP Antibody (aa2-35) - LS-C344426 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from 293 cell line with PAXIP1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35 ug.

PTIP Antibody - NBP2-33877 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTIP Antibody [NBP2-33877] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Negative control (vector only transfected HEK293T lysate)Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY402132)

PTIP Antibody - NB100-576 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PTIP Antibody [NB100-576] - Detection of Human PTIP on HeLa whole cell lysate using NB100-576. PTIP was also IPed using rabbit anti-PTIP antibody NB100-577 Immunoprecipitated PTIP was detected using BL1787.

PTIP Antibody - NBP1-88233 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTIP Antibody [NBP1-88233] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted)

PTIP Antibody - NB100-577 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTIP Antibody [NB100-577] - Detection of Human PTIP on HeLa whole cell lysate using NB100-577. PTIP was also immunoprecipitated using rabbit anti-PTIP antibody NB100-576. Immunoprecipitated PTIP was detected using BL1789.

PTIP Antibody - H00022976-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

PTIP Antibody - H00022976-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

PTIP Antibody (4C11) - H00022976-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C11
Immunocytochemistry/Immunofluorescence: PTIP Antibody (4C11) [H00022976-M02] - Analysis of monoclonal antibody to PAXIP1 on HeLa cell. Antibody concentration 10 ug/ml.

Anti-PAXIP1 antibody produced in rabbit - AV51642 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: 721_B (<B>Cat. No. AV51642</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type 721_B

Monoclonal Anti-PAXIP1 antibody produced in mouse - WH0022976M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C11
<B>Immunoblotting</B><BR/>Monoclonal Anti-PAXIP1, <B>Cat. No. WH0022976M2</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.99 kDa using immunogen protein lysate.

Anti-PAXIP1 antibody produced in mouse - SAB1409011 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-PAXIP1: <B>Cat. No. SAB1409011</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-PAXIP1 antibody produced in rabbit - HPA016950 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PAXIP1: <B>Cat. No. HPA016950</B>: Immunohistochemical staining of Human small intestine shows strong nuclear positivity in glandular cells.
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