| Gene Symbol |
KL
|
| Entrez Gene |
9365
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
klotho
|
| Other Description |
-
|
| Swissprots |
Q96KV5 Q9UEI9 Q5VZ95 Q96KW5 Q9UEF7 Q9Y4F0
|
| Accessions |
BAA24940 BAA24941 BAL03067 CAC94767 CAC94773 CAR95139 EAX08525 EAX08526 Q9UEF7 AA890465 AB005142 BAA23382 AK097349 BAG53456 CB988086 XM_006719895 XP_006719958 NM_004795 NP_004786 NM_153683
|
| Function |
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Klotho peptide: Secreted.
|
| Tissue Specificity |
Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:11162628, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9464267}.
|
| Top Pathways |
Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism
|
![Western Blot: Klotho Overexpression Lysate (Adult Normal) [NBL1-12307] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Klotho.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9528_Klotho%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12307-img0002.jpg)