KL

Gene Symbol KL
Entrez Gene 9365
Alt Symbol -
Species Human
Gene Type protein-coding
Description klotho
Other Description -
Swissprots Q96KV5 Q9UEI9 Q5VZ95 Q96KW5 Q9UEF7 Q9Y4F0
Accessions BAA24940 BAA24941 BAL03067 CAC94767 CAC94773 CAR95139 EAX08525 EAX08526 Q9UEF7 AA890465 AB005142 BAA23382 AK097349 BAG53456 CB988086 XM_006719895 XP_006719958 NM_004795 NP_004786 NM_153683
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). {ECO:0000250}.
Subcellular Location Klotho peptide: Secreted.
Tissue Specificity Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:11162628, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9464267}.
Top Pathways Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism

Klotho (T-19) - sc-22218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Klotho (E-21) - sc-22220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Klotho (E-21): sc-22220. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

Anti-Klotho antibody - ab203576 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse kidney tissue labeling Klotho with ab203576 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-Klotho antibody - ab98111 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Klotho antibody (ab98111) at 1 µg/ml (in 5% skim milk / PBS buffer) + NCI-H226 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Klotho antibody - ab18131 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Klotho antibody - ab98171 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Klotho antibody (ab98171) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Klotho antibody [EPR6856] - ab181373 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6856
All lanes : Anti-Klotho antibody [EPR6856] (ab181373) at 1/1000 dilution (purified)Lane 1 : Human fetal kidneyLane 2 : Human testisLane 3 : Human fetal thymusLysates/proteins at 20 µg per lane.SecondaryHRP anti-rabbit IgG, specific to the non-reduced form of IgG at 1/1000 dilution

Anti-KL / Klotho Antibody (clone 236214) - LS-C150215 from LifeSpan Bioscience

Prices $385.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone 236214

Anti-KL / Klotho Antibody (aa467-516) - LS-C107624 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KL / Klotho antibody LS-C107624 Western blot of PANC1 cell lysate.

Anti-KL / Klotho Antibody (aa100-149) - LS-C145689 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KL / Klotho antibody LS-C145689 Western blot of Small Intestine lysate. Antibody concentration 1 ug/ml.

Anti-KL / Klotho Antibody (aa61-110) - LS-C107829 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KL / Klotho antibody LS-C107829 Western blot of Fetal Thymus lysate.

Anti-KL / Klotho Antibody (aa517-956, Biotin) - LS-C297820 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KL / Klotho Antibody (aa516-955, Biotin) - LS-C297819 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KL / Klotho Antibody - LS-C150214 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Klotho in Mouse Kidney. Klotho was detected in perfusion fixed frozen sections of mouse kidney using 1.7 ug/ml Mouse Klotho Antigen Affinity-purified Polyclonal Antibody overnight at 4°C. Tissue was stained with Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

Anti-KL / Klotho Antibody (aa59-508, FITC) - LS-C304153 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KL / Klotho Antibody (aa59-508, Biotin) - LS-C299983 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KL / Klotho Antibody (aa516-955, FITC) - LS-C305219 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KL / Klotho Antibody (aa517-956, FITC) - LS-C305218 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KL / Klotho Antibody (aa516-955) - LS-C295045 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant KL / Klotho.

Anti-KL / Klotho Antibody (aa517-956) - LS-C295046 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant KL / Klotho.

Anti-KL / Klotho Antibody (aa59-508) - LS-C295049 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant KL / Klotho.

Anti-KL / Klotho Antibody (aa720-769) IHC-plus™ - LS-B5728 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Klotho antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5728 concentration 5 ug/ml.

Anti-KL / Klotho Antibody (aa374-466) IHC-plus™ - LS-B11610 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-KL / Klotho Antibody (Internal) IHC-plus™ - LS-B7010 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Klotho antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7010 concentration 5 ug/ml.

Anti-KL / Klotho Antibody (C-Terminus) - LS-C8375 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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