KL

Gene Symbol	KL
Entrez Gene	9365
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	klotho
Other Description	-
Swissprots	Q96KV5 Q9UEI9 Q5VZ95 Q96KW5 Q9UEF7 Q9Y4F0
Accessions	BAA24940 BAA24941 BAL03067 CAC94767 CAC94773 CAR95139 EAX08525 EAX08526 Q9UEF7 AA890465 AB005142 BAA23382 AK097349 BAG53456 CB988086 XM_006719895 XP_006719958 NM_004795 NP_004786 NM_153683
Function	May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). {ECO:0000250}.
Subcellular Location	Klotho peptide: Secreted.
Tissue Specificity	Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:11162628, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9464267}.
Top Pathways	Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Active human Klotho protein fragment - ab84072 from Abcam Category Protein Prices $110.00, $316.00 Sizes 5 µg, 20 µg Source CHO Species Human

KL / Klotho Antibody Blocking Peptide - LS-E31051 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KL / Klotho Antibody Blocking Peptide - LS-E7222 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KL / Klotho Antibody Blocking Peptide - LS-E25987 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KL / Klotho Antibody Blocking Peptide - LS-E26941 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KL / Klotho Antibody Blocking Peptide - LS-E15296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KL / Klotho Antibody Blocking Peptide - LS-E15295 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KL / Klotho Antibody Blocking Peptide - LS-E15294 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Klotho Blocking Peptide - NB100-2432PEP from Novus Biologicals Category Peptide Prices $229.00 Sizes 100 µg Species Human

Klotho Blocking Peptide - NBP1-76511PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Klotho-Antibody-C-term-Blocking-Peptide - BP2945b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Klotho Recombinant Protein (Active) - GTX48092-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source Hamster Species Human

Klotho blocking peptide - GTX89443-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Klotho blocking peptide - GTX88452-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Klotho (aa 34-981), CF - 5334-KL-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu34-Ser981, with a C-terminal 6-His tag

Klotho Blocking Peptide - 33R-3695 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Klotho Blocking Peptide - 33R-3841 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Klotho Blocking Peptide - 33R-3536 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Klotho Blocking Peptide - 33R-3012 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Klotho protein - 30R-AK008 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source CHO cells

Klotho Peptide - AC21-0815-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Klotho Peptide - AC21-1770-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Klotho - AR08005PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source CHO cells Species Human

Klotho - AR08005PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source CHO cells Species Human

Klotho - AR31175PU-N from Acris Antibodies Category Protein Prices $320.00 Sizes 20 µg Source CHO cells Species Human

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