Gene Symbol |
PRPF3
|
Entrez Gene |
9129
|
Alt Symbol |
HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
pre-mRNA processing factor 3
|
Other Description |
PRP3 pre-mRNA processing factor 3 homolog|U4/U6 small nuclear ribonucleoprotein Prp3|U4/U6 snRNP 90 kDa protein|U4/U6-associated RNA splicing factor|pre-mRNA-splicing factor 3
|
Swissprots |
O43395 Q5VT54 O43446 B4DSY9
|
Accessions |
EAW53556 O43395 AF001947 AAC09069 AF016370 AAC51926 AK222825 BAD96545 AK297139 BAG59640 AK297265 BAG59740 AK299980 BAG61801 AK309330 AK310241 AK311653 AK312891 BAG35738 BC000184 AAH00184 BC001954 AAH01954 BQ002848 DC407158 DQ892853 ABM83779 DQ896100 ABM87099 XM_011510128 XP_011508430 XM_011510129 XP_011508431 XM_011510130 XP_011508432 XM_011510131 XP_011508433 XM_011510132 XP_011508434 XR_241103 XR_241104 XR_921997 XR_921998 NM_004698 NP_004689
|
Function |
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. {ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889, ECO:0000303|PubMed:20595234}.
|
Subcellular Location |
Nucleus speckle. Note=Colocalizes with spliceosomal snRNPs.
|
Tissue Specificity |
Highly expressed in retina, liver, kidney and blood. Detected at lower levels in heart and brain. {ECO:0000269|PubMed:11773002}.
|
Top Pathways |
Spliceosome
|