GCK

Gene Symbol GCK
Entrez Gene 2645
Alt Symbol FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species Human
Gene Type protein-coding
Description glucokinase (hexokinase 4)
Other Description ATP:D-hexose 6-phosphotransferase|HK IV|glucokinase|hexokinase D, pancreatic isozyme|hexokinase type IV|hexokinase-4|hexokinase-D
Swissprots A4D2J2 A4D2J3 Q05810 P35557
Accessions AAA67541 AAA67542 AAB97680 AAB97681 AAB97682 AGA96145 AGH08211 AGH08212 AGH08213 AGH08214 AGH08215 AGH08216 AGH08217 AGH08218 AGH08220 AGH08221 AGH08222 AGH08223 CBF63115 CBU87991 EAL23764 EAL23765 EAL23766 EAW61114 EAW61115 EAW61116 P35557 AK122876 BAG53774 BC001890 AAH01890 BT007062 AAP35711 CD251038 DA640823 DQ893835 ABM84761 EU008605 ABS31137 M69051 AAB59563 M88011 AAA51824 M90299 AAA52562 NM_000162 NP_000153 NM_033507 NP_277042 NM_033508 NP_277043
Function Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Top Pathways Glucagon signaling pathway, Central carbon metabolism in cancer, Insulin signaling pathway, Prolactin signaling pathway, Glycolysis / Gluconeogenesis

GCK (H-88) - sc-7908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GCK (H-88): sc-7908. Western blot analysis of GCK expression in rat pancreas extract.

GCK (C-20) - sc-1979 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GCK (C-20): sc-1979. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic and nuclear staining of exocrine glandular cells and Islets of Langerhans.

GCK (G-6) - sc-17819 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GCK (G-6): sc-17819. Western blot analysis of human recombinant GCK fusion protein.

GCK (N-19) - sc-1980 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GCK (N-19): sc-1980. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

GCK (G-5) - sc-55496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GCK (G-5): sc-55496. Western blot analysis of human recombinant GCK protein.

GCK (W-24) - sc-130765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
GCK (W-24): sc-130765. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic and membrane localization.

Anti-GLK antibody - ab88056 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GLK antibody (ab88056) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µg/mlSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-GLK antibody - ab137714 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GLK antibody (ab137714) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-GLK antibody - ab70857 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GLK antibody (ab70857) at 1/100 dilution + mouse lung tissue lysate at 12.5 µg

Anti-GLK antibody [3E3] - ab117856 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E3
All lanes : Anti-GLK antibody [3E3] (ab117856) at 1/500 dilutionLane 1 : HEK293T lysate transfected with pCMV6-ENTRY control cDNA for 48 hrs Lane 2 : HEK293T lysate transfected with pCMV6-ENTRY GLK cDNA for 48 hrs Lysates/proteins at 5 µg per lane.

Anti-GLK antibody [EPR10374] - ab155962 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10374
Anti-GLK antibody [EPR10374] (ab155962) at 1/50000 dilution + BxPC-3 cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GLK antibody - N-terminal - ab37796 from Abcam

Prices $398.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GLK antibody - N-terminal (ab37796)Lane 1 : Hep G2 cell lysateLane 2 : Mouse liver lysate

Anti-IGLK antibody - ab134755 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IGLK antibody (ab134755) at 1/500 dilution + NIH 3T3 cell extract at 30 µg

Anti-IGLK antibody - ab28429 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (clone 3E3) - LS-C114560 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E3
IHC of paraffin-embedded Carcinoma of lung tissue using anti-GCK mouse monoclonal antibody. (Dilution 1:50).

Anti-GCK / Glucokinase Antibody - LS-C146878 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody - LS-C146879 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (C-Terminus, AP) - LS-C278068 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (aa84-133) - LS-C145627 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GCK / Glucokinase antibody LS-C145627 Western blot of COL0205 Cell lysate. Antibody concentration 1 ug/ml.

Anti-GCK / Glucokinase Antibody (C-Terminus, APC) - LS-C278070 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (C-Terminus, Biotin) - LS-C278071 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (C-Terminus, FITC) - LS-C278072 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (C-Terminus, Azide-free, HRP) - LS-C278073 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCK / Glucokinase Antibody (Arg43) - LS-C177249 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GCK (R43) pAb in extracts from NIH-3T3 cells.

Anti-GCK / Glucokinase Antibody (C-Terminus, PE) - LS-C278074 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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