GCK

Gene Symbol	GCK
Entrez Gene	2645
Alt Symbol	FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species	Human
Gene Type	protein-coding
Description	glucokinase (hexokinase 4)
Other Description	ATP:D-hexose 6-phosphotransferase|HK IV|glucokinase|hexokinase D, pancreatic isozyme|hexokinase type IV|hexokinase-4|hexokinase-D
Swissprots	A4D2J2 A4D2J3 Q05810 P35557
Accessions	AAA67541 AAA67542 AAB97680 AAB97681 AAB97682 AGA96145 AGH08211 AGH08212 AGH08213 AGH08214 AGH08215 AGH08216 AGH08217 AGH08218 AGH08220 AGH08221 AGH08222 AGH08223 CBF63115 CBU87991 EAL23764 EAL23765 EAL23766 EAW61114 EAW61115 EAW61116 P35557 AK122876 BAG53774 BC001890 AAH01890 BT007062 AAP35711 CD251038 DA640823 DQ893835 ABM84761 EU008605 ABS31137 M69051 AAB59563 M88011 AAA51824 M90299 AAA52562 NM_000162 NP_000153 NM_033507 NP_277042 NM_033508 NP_277043
Function	Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity	Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Top Pathways	Glucagon signaling pathway, Central carbon metabolism in cancer, Insulin signaling pathway, Prolactin signaling pathway, Glycolysis / Gluconeogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GCK-Over-expression-Lysate - LY10331a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GCK 293T Cell Transient Overexpression Lysate(Denatured) - H00002645-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GCK 293T Cell Transient Overexpression Lysate(Denatured) - H00002645-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GCK overexpression lysate - LY403250 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

GCK overexpression lysate - LY409539 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

GCK overexpression lysate - LY429881 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GCK 293 Cell Lysate - 400153 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

GCK 293 Cell Lysate - 402822 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

GCK 293 Cell Lysate - 404998 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Glucokinase/GCK Overexpression Lysate (Denatured) - H00002645-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Glucokinase/GCK Overexpression Lysate (Denatured) - H00002645-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Glucokinase/GCK Overexpression Lysate (Native) - NBL1-11009 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Glucokinase/GCK Overexpression Lysate (Native) - NBP2-05877 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Glucokinase/GCK Overexpression Lysate (Native) - NBL1-11008 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GCK (h): 293T Lysate - sc-170722 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

GCK Over-expression Lysate Product - GWB-E56019 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

GCK Over-expression Lysate Product - GWB-DA945F from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

GCK Over-expression Lysate Product - GWB-1618E5 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Glucokinase/GCK Overexpression Lysate (Native) - NBP2-09947 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human GCK Knockdown Stable Cell Line - CSC-DC006163 from Creative biogene Category Cell Line Species Human

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